Publications by authors named "Claire Nicolas De Lamballerie"
An increasing amount of evidence indicates a relatively high prevalence of superinfections associated with coronavirus disease 2019 (COVID-19), including invasive aspergillosis, but the underlying mechanisms remain to be characterized. In the present study, to better understand the biological impact of superinfection, we determine and compare the host transcriptional response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) versus superinfection, using a model of reconstituted human airway epithelium. Our analyses reveal that both simple infection and superinfection induce strong deregulation of core components of innate immune and inflammatory responses, with a stronger response to superinfection in the bronchial epithelial model compared to its nasal counterpart.
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- Human respiratory syncytial virus (HRSV) is a leading cause of respiratory infections in infants and neonates globally.
- The study utilized a specialized transcriptomics approach on nasal wash samples from children with HRSV to explore how the virus interacts with the host's immune response.
- Findings identified a specific immune signature linked to HRSV infection, revealing potential new biomarkers like IP-10, TMEM190, MCEMP1, and TIMM23 for diagnosis and treatment.
Human metapneumovirus (HMPV) is a major pediatric respiratory pathogen with currently no specific treatment or licensed vaccine. Different strategies to prevent this infection have been evaluated, including live-attenuated vaccines (LAV) based on SH and/or G protein deletions. This approach showed promising outcomes but has not been evaluated further using different viral strains.
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- Acute respiratory infections, mostly caused by viruses, are a big health problem that needs new treatment options.
- In this study, scientists used a technique called RNAseq to look at how different respiratory viruses, like the flu, hRSV, and hMPV, affect human airway cells.
- They found that these viruses change how certain genes work, especially genes related to cilia, which are tiny hair-like structures that help clear mucus from our lungs.
Influenza virus infections remain a major and recurrent public health burden. The intrinsic ever-evolving nature of this virus, the suboptimal efficacy of current influenza inactivated vaccines, as well as the emergence of resistance against a limited antiviral arsenal, highlight the critical need for novel therapeutic approaches. In this context, the aim of this study was to develop and validate an innovative strategy for drug repurposing as host-targeted inhibitors of influenza viruses and the rapid evaluation of the most promising candidates in Phase II clinical trials.
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