Publications by authors named "Claire Min-Li Teo"
The underlying immunological mechanisms of immediate-type hypersensitivity reactions (HSR) to COVID-19 vaccines are poorly understood. We investigate the mechanisms of immediate-type hypersensitivity reactions to the Pfizer BNT162b2 vaccine and the response of antibodies to the polyethylene glycol (PEG)ylated lipid nanoparticle after two doses of vaccination. Sixty-seven participants, median age 35 and 77.
View Article and Find Full Text PDFDuring the initial rollout of coronavirus disease 2019 (COVID-19) vaccination in Singapore, the Ministry of Health (MOH) issued a recommendation that patients with a history of any previous vaccine allergy be referred to an allergist for further review of their suitability to proceed with mRNA-based COVID-19 vaccines. Patients fulfilling the above criterion were divided into three groups: immediate reaction (Group A), delayed reaction (Group B) and no/irrelevant reaction (Group C). They were subjected to either a skin prick test (SPT) and intradermal test (IDT) with polyethylene glycol (PEG) or polysorbate-containing products; direct injection with the Pfizer BNT162b2 vaccine in the allergy clinic; or injection at community vaccination centres, respectively.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate how effective bisphosphonates are in increasing bone mineral density (BMD) and reducing fractures in patients who have undergone orthotopic liver transplants (OLT).
- A total of nine studies were analyzed, indicating that bisphosphonates led to significantly lower fracture rates (6.6%) compared to calcium and vitamin D (19.1%).
- While both oral and IV bisphosphonates were beneficial, oral formulations were more effective than IV in reducing bone loss and fractures post-OLT.
Article Synopsis
- Osteoporosis is a major complication after liver transplants, with a notable increase in cases and fractures compared to non-transplant patients.
- A meta-analysis found that 34.53% of liver transplant patients develop osteopenia, 11.68% osteoporosis, and 20.40% experience fractures.
- Key risk factors for fractures include older age, lower bone mineral density before the transplant, and pre-existing bone diseases, while being female does raise osteoporosis risk but not fracture risk.