Publications by authors named "Claire Mazoyer"
Article Synopsis
- Ovarian cortex cryopreservation can restore fertility in young women after cancer, but grafts have a limited lifespan due to ischemia.
- This study compared slow freezing and vitrification techniques for preserving whole ovaries in ewes and assessed the effectiveness of each method.
- Results showed that while both methods allowed hormonal recovery, vitrification led to significantly better follicle survival rates compared to slow freezing, suggesting it could be a more effective cryopreservation option for future fertility preservation.
Article Synopsis
- The study aimed to assess the viability of ovarian follicles and the quality of ovarian tissue after they undergo freezing and thawing processes.
- Ewe's ovaries were divided into fresh tissues (control group) and frozen tissues, with various tests performed to evaluate follicle viability and tissue quality, showing decreased viability after cryopreservation.
- Results indicated a strong correlation between follicle viability and the methods used for assessment, while also noting increased cytotoxicity and no significant differences in DNA fragmentation between the groups.
Extracellular matrix (ECM) formation by cumulus cells is an important process that determines fertilization and embryo quality. Several collagen types are present in the ovarian follicular ECM and are related to proliferation, steroidogenesis, and luteinization. In vitro mouse follicles can optimally grow and provide developmentally competent oocytes with 10 IU/L recombinant follicle-stimulating hormone (rFSH).
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- - This study evaluated the recovery of ovarian function and fertility in ewes after either transplanting or cryopreserving (vitrifying) whole ovaries at a veterinary school in France.
- - Two groups of ewes were compared: one underwent immediate transplantation of the ovary, while the other had their ovary frozen and then thawed before transplantation.
- - Results showed that although the transplantation was successful for both groups, the follicle survival rate was only 6% in the immediate transplant group, and none survived in the vitrified group, despite some ewes recovering endocrine function and giving birth to lambs.
Objective: To examine sperm DNA fragmentation in semen used for assisted reproduction procedures to establish this factor's prognostic role in fertilization rate, embryo development, pregnancy rate, and outcome.
Design: Prospective study.
Setting: Department of Medicine and Biology of Reproduction of the Edouard Herriot Hospital in Lyon, France.
Objective: To study the thermal properties of a cryoprotectant solution, called VS4, and of VS4-impregnated whole sheep ovaries with pedicle.
Design: Physical and experimental animal study.
Setting: Academic research environment.
Objective: To evaluate a cryopreservation technique by vitrification of whole ovaries with their vascular pedicle in sheep, by using two cryoprotectant solutions.
Design: Animal study.
Setting: Fertility clinic in a university teaching hospital.