Does gender, food or grapefruit juice alter the pharmacokinetics of primaquine in healthy subjects?

Aims: To evaluate the effects of gender, food and grapefruit juice on the pharmacokinetics of primaquine in healthy subjects.

Methods: In a randomized, two-phase cross-over study, 10 male and 10 female healthy Vietnamese subjects were administered 30 mg primaquine in the fasting state or with food, followed by administration of primaquine with grapefruit juice.

Results: The pharmacokinetics of primaquine were comparable between male and female subjects, with geometric mean ratios of Cmax = 0.