Extracellular Matrices and Cancer-Associated Fibroblasts: Targets for Cancer Diagnosis and Therapy?

Solid cancer progression is dictated by neoplastic cell features and pro-tumoral crosstalks with their microenvironment. Stroma modifications, such as fibroblast activation into cancer-associated fibroblasts (CAFs) and extracellular matrix (ECM) remodeling, are now recognized as critical events for cancer progression and as potential therapeutic or diagnostic targets. The recent appreciation of the key, complex and multiple roles of the ECM in cancer and of the CAF diversity, has revolutionized the field and raised innovative but challenging questions.

[Alcohol, an addiction like any other].

The current treatment available to people in difficulty with regard to their consumption of alcohol is not merely limited to forced abstinence. It benefits from the advances made in addictology and research into treatment based on the concept of controlled consumption. In the framework of a therapeutic alliance, multidisciplinary teams offer medication-based treatments and individualised and diversified psycho-social treatment.