Publications by authors named "Claire L O'Neill"
Forty years of IVF.
Craig Niederberger Antonio Pellicer Jacques Cohen David K Gardner Gianpiero D Palermo Claire L O'Neill
Fertil Steril
July 2018
This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the history, achievements, and medical advancements made over the last 40 years in this rapidly growing field.
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- The initial step in activating gene expression after fertilization involves the derepression of chromatin from both parental genomes, with H3.3 playing a key role in this process.
- Sperm-derived H3.3 is quickly removed from the genome after fertilization, while maternal H3.3 integrates into the paternal genome shortly afterward, indicating its importance in early developmental stages.
- Reducing maternal H3.3 negatively impacts embryonic development, suggesting that this histone variant is crucial for remodeling paternal chromatin and initiating early gene expression in developing embryos.