Publications by authors named "Claire L McIntyre"
Article Synopsis
- γδ T cells play a crucial role in maintaining tissue health and are linked to better outcomes in various tumors, but their specific characteristics in human cancers are not well understood.
- In studies of colorectal and endometrial cancer, significant differences were observed in γδ T cell subsets and their functions between tumor and normal tissues; colorectal cancer displayed a specific AREG-producing subset, while endometrial cancer had more cytotoxic γδ cells.
- A new expansion method was developed to enhance the cytotoxic abilities of γδ T cells for potential use in cell therapy, improving tumor infiltration and clearance while reducing AREG production, thus presenting a promising ‘off-the-shelf’ treatment strategy.
Nutrients are essential for cell function. Immune cells operating in the complex tumor microenvironment (TME), which has a unique nutrient composition, face challenges of adapting their metabolism to support effector functions. We discuss the impact of nutrient availability on immune function in the tumor, competition between immune cells and tumor cells for nutrients, and how this is altered by diet.
View Article and Find Full Text PDFβ2 Integrins differentially regulate γδ T cell subset thymic development and peripheral maintenance.
Proc Natl Acad Sci U S A
September 2020
The γδ T cells reside predominantly at barrier sites and play essential roles in immune protection against infection and cancer. Despite recent advances in the development of γδ T cell immunotherapy, our understanding of the basic biology of these cells, including how their numbers are regulated in vivo, remains poor. This is particularly true for tissue-resident γδ T cells.
View Article and Find Full Text PDFObjectives: Successful early intervention in rheumatoid arthritis (RA) with the aim of resetting immunological tolerance requires a clearer understanding of how specificity, cellular kinetics and spatial behaviour shape the evolution of articular T cell responses. We aimed to define initial seeding of articular CD4 T cell responses in early experimental arthritis, evaluating their dynamic behaviour and interactions with dendritic cells (DCs) in the inflamed articular environment.
Methods: Antigen-induced arthritis was used to model articular inflammation.