William M. Reynolds (1951-2024).

Memorializes William M. Reynolds (1951-2024). "Bill" served as director of the graduate program in school psychology at the University of Wisconsin-Madison and held appointments as principal investigator at the Waisman Center on Mental Retardation and Human Development and as discipline chief of Psychology of the University Affiliated Program at the Waisman Center.

Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.

Aggregates of the protein tau are proposed to drive pathogenesis in neurodegenerative diseases. Tau can be targeted by using passively transferred antibodies (Abs), but the mechanisms of Ab protection are incompletely understood. In this work, we used a variety of cell and animal model systems and showed that the cytosolic Ab receptor and E3 ligase TRIM21 (T21) could play a role in Ab protection against tau pathology.

Cholesterol determines the cytosolic entry and seeded aggregation of tau.

Assemblies of tau can transit between neurons, seeding aggregation in a prion-like manner. To accomplish this, tau must cross cell-limiting membranes, a process that is poorly understood. Here, we establish assays for the study of tau entry into the cytosol as a phenomenon distinct from uptake, in real time, and at physiological concentrations.

Local emergency management's use of social media during disasters: a case study of Hurricane Irma.

Governments' use of social media during all phases of emergency management, especially during disasters, has increased dramatically in the past 20 years. Yet, implementation at the local government level in the United States remains haphazard. As technology and the role of social media evolve, there persists a need to understand the socio-technical aspects of social media's employment in times of disaster.

Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.

A fundamental property of infectious agents is their particulate nature: infectivity arises from independently-acting particles rather than as a result of collective action. Assemblies of the protein tau can exhibit seeding behaviour, potentially underlying the apparent spread of tau aggregation in many neurodegenerative diseases. Here we ask whether tau assemblies share with classical pathogens the characteristic of particulate behaviour.

Disaster Recovery Communication in the Digital Era: Social Media and the 2016 Southern Louisiana Flood.

This study explores disaster recovery communication in the digital era. In particular, this study analyzes Twitter communication data corresponding to the 2016 Southern Louisiana flood recovery process and examines patterns and characteristics of long-term recovery communication. Based on network and sentiment analyses of the longitudinal Twitter data, the study identifies the dynamic changes in participants' numbers, dominant voices, and sentiments in social media communication during the long-term recovery process.

A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue.

Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2.

Advancing emergency management higher education: Importance of cultural competence scholarship.

The evolving demographics, needs, and demands of society requires managers to be culturally competent in all phases of emergency management, especially when responding to disasters. A culturally incompetent manager and/or organization can increase a hazard's impact on often already vulnerable communities. Are cultural competencies lacking in emergency management education? Are these competencies as important as other highly regarded emergency management competencies? What are effective pedagogy and andragogy to create, implement, and evaluate cultural competency in emergency management higher education? As scholars work to advance the emergency management discipline, there is an increasing need for scholarship of teaching and learning research, especially regarding cultural competency.

The scholarship of teaching and learning in emergency management and homeland security: Trends, gaps, barriers, and opportunities.

Underlying the nature of what is and is not a profession are education standards. Among the characteristics defining a profession's specialized boundaries are the education standards comprising its academic programs. The status of the Scholarship of Teaching and Learning (SoTL) is explored for both emergency management and homeland security (EM/HS) at this point in time.

Unveiling cultures in emergency response communication networks on social media: following the 2016 Louisiana floods.

While culture in emergency management has gained attention from the field of risk communication, few have systemically dealt with the nuances of general culture involved in the formation and differentiation of risk communication. To fill this gap, this research aims to first examine cultural nuances from the 2016 Louisiana flood response by primarily focusing on communications embedded in social media. The results from social network analysis and content analysis highlight that the flood response communication had strong cultural characteristics, highlighting the notion that of the cultures in Louisiana-faith-based, local authority, and nonprofits-were the prominent cultural responders in the flood response communication.

Evolution of an experiential learning partnership in emergency management higher education.

Experiential learning allows students to step outside the classroom and into a community setting to integrate theory with practice, while allowing the community partner to reach goals or address needs within their organization. Emergency Management and Homeland Security scholars recognize the importance, and support the increased implementation, of this pedagogical method in the higher education curriculum. Yet challenges to successful implementation exist including limited resources and time.

Analyzing after-action reports from Hurricanes Andrew and Katrina: repeated, modified, and newly created recommendations.

Thirteen years after Hurricane Andrew struck Homestead, FL, Hurricane Katrina devastated the Gulf Coast of Mississippi, Alabama, and southeastern Louisiana. Along with all its destruction, the term "catastrophic" was redefined. This article extends the literature on these hurricanes by providing a macrolevel analysis of The Governor's Disaster Planning and Response Review Committee Final Report from Hurricane Andrew and three federal after-action reports from Hurricane Katrina, as well as a cursory review of relevant literature.