Publications by authors named "Claire K Y Neuwirth"
J Lipid Res
December 2013
Article Synopsis
- The study aimed to identify key biological processes affected in the subcutaneous fat tissue of patients with familial combined hyperlipidemia (FCHL), revealing a unique FCHL transcriptome involved in various systems like cytoskeleton and lipid regulation.
- Expression levels of the cell-cycle inhibitor CDKN2B were found to be elevated, and its knockdown in lab cells increased lipid accumulation, indicating a link between CDKN2B and fat storage.
- The research suggests that dysfunctional fat tissue development is a critical aspect of FCHL, although other external factors might also contribute to the increased CDKN2B expression and lipid problems in these patients.
