Prospective evaluation of a new ultrathin one-plane bending videoendoscope for transnasal EGD: a comparative study on performance and tolerance.

Background: EGD, with small-diameter endoscopes, is routinely performed via a nasal route in adults.

Objective: To evaluate a new ultrathin one-plane bending videoendoscope for transnasal EGD.

Design: Single center, prospective, randomized study.

Reduction of menin expression enhances cell proliferation and is tumorigenic in intestinal epithelial cells.

Menin, the product of the tumor suppressor gene MEN1, is widely expressed in mammalian endocrine and non-endocrine tissues, including intestine. Its known abundant expression in several types of cells with high proliferative capacity led us to investigate the physiological function of the protein menin in intestinal epithelium, one of the most rapidly growing epithelia. Here we showed that the Men1 gene is mainly expressed in the crypt compartment of the proximal small intestine and that its expression was increased during fasting in vivo, both suggesting a role of menin in the control of cell growth.