Publications by authors named "Claire Jh Kramer"
J Pathol Clin Res
November 2023
Article Synopsis
- The RAD51 test is being explored as a potential biomarker for assessing homologous recombination deficiency (HRD) in ovarian cancer, but its reliability across different labs hasn't been fully assessed.
- In a study involving four European laboratories, slight differences in staining techniques led to low variability in RAD51 and γH2AX scores, but some samples showed significant scoring variability due to technical and biological issues.
- The findings highlight the importance of improving quality control and potentially automating image analysis for the RAD51 test to better identify HRD in high-grade serous ovarian carcinoma (HGSOC) patients, which is crucial for personalized treatment approaches.
