Publications by authors named "Claire Hotz"
Objectives: To investigate factors associated with dermatomyositis (DM) complete clinical response and overall survival with a focus on the use of immunosuppressive therapies in patients with cancer-associated DM.
Methods: We performed a multicentre, retrospective cohort study. Multivariable survival analyses used a Cox model with time-dependent covariates and adjustments with inverse probability censoring weighting.
Hidradenitis suppurativa (HS) is a chronic skin disease characterized by painful, recurrent abscesses, nodules, and scarring, primarily in skin folds. The exact causes of HS are multifactorial, involving genetic, hormonal, and environmental factors. It is associated with systemic diseases such as metabolic syndrome and inflammatory bowel disease.
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- * A study of 120 patients showed that 36% achieved complete cutaneous remission after one year, with oral corticosteroids and a hydroxychloroquine/topical steroids combo yielding the best results.
- * The findings suggest using hydroxychloroquine and topical steroids as the best first-line treatment due to the negative side effects associated with systemic corticosteroids, with lupus pernio being a predictor of poor response.
Although retinoids are considered as the most effective treatment, management of dissecting cellulitis of the scalp (DCS) is often challenging. A multicentre retrospective study was conducted to evaluate the efficacy of anti-tumour necrosis factor (TNF) agents in treating DCS after failure of other conventional treatments. Twenty-six patients were included.
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- * Research involving gene expression profiling of skin biopsies from DI-Pso patients revealed significant activation of the T helper 17/IL-23 pathways, alongside increased IL-36 expression, which is a marker of pustular psoriasis.
- * The findings indicate a shift in immune response from T helper 2 to T helper 17 in DI-Pso cases, coupled with notable skin barrier dysfunction compared to healthy individuals and those with other skin conditions.
Health products e-sale should be regulated: a case of necrotizing soft-tissue infection of the abdomen linked to self-injection of slimming products purchased on the internet.
Int J Dermatol
February 2022
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition substantially impacting patients' quality of life; the pathogenesis remains unclear, and treatment is complex and not yet standardized. Observational data are increasingly being used to evaluate therapeutics in "real-life" interventions, and the development of e-cohorts is offering new tools for epidemiological studies at the population level.
Objective: The aim of this study was to describe the clinical characteristics and treatment history of HS participants in the Community of Patients for Research (ComPaRe) cohort and to compare these to other cohorts.
Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin disease. HS appears to be a primary abnormality in the pilosebaceous-apocrine unit. In this work, we characterized hair follicle stem cells (HFSCs) isolated from HS patients and more precisely the outer root sheath cells (ORSCs).
View Article and Find Full Text PDFCyclosporine has shown promising results for mortality in patients with Stevens-Johnson syndrome/toxic epidermal necrolysis. However, available studies included only a small number of patients and did not include a validated and homogenous control group. We present the results from a retrospective monocentric study including 174 patients with Stevens-Johnson syndrome/toxic epidermal necrolysis during 2005-2016.
View Article and Find Full Text PDFHidradenitis suppurativa (HS) is a chronic, inflammatory, debilitating, follicular disease of the skin. Despite a high prevalence in the general population, the physiopathology of HS remains poorly understood. The use of antibiotics and immunosuppressive agents for therapy suggests a deregulated immune response to microflora.
View Article and Find Full Text PDFBackground: Specific cutaneous lesions of Waldenström macroglobulinemia are rare and include neoplastic cell infiltrates, IgM bullous disease, and so-called IgM-storage papules, which characterize cutaneous macroglobulinosis (CM).
Observations: We report 2 patients with CM. In patient 1, CM started as small papules, as reported in most of the previously published case studies of CM.
Quinolone-resistant Neisseria gonorrhoeae rates have increased worldwide since 1994. The objective of this study was to appraise: (i) the antimicrobial susceptibility of Neisseria gonorrhoeae in a venereology clinic in Paris, between 2005 and 2007; and (ii) the factors associated with quinolone-resistant N. gonorrhoeae.
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