Breaking good? Young people's mechanisms of resilience, resistance and control.

The conventional understanding of resilience often portrays it as a positive outcome emerging from adverse situations. This perspective frequently shapes interventions aimed at bolstering resilience among individuals considered to be in need. Drawing upon data from a European study, this paper contends that young people's apparent 'latent rejection' of favourable opportunities, or their deliberate choice to remain in precarious situations despite having some agency, should be recontextualised as unconventional but valid expressions of resilience.

Molecular analysis and favorable clinical outcomes in real-world patients with metastatic renal cell carcinoma.

Background: Prior biomarker studies have mainly been restricted to advanced RCC patients treated in clinical trials or have had limited integration of immunotherapy features such as programmed death ligand (PD-L)-1 with gene expression signatures intended to capture other canonical pathways to confirm their prognostic value.

Material And Methods: PD-L1 and PD-L2 by immunohistochemistry (IHC), PD-L2 messenger RNA (mRNA), and 10 gene expression profile (GEP) signatures targeting immune, angiogenesis and canonical pathways were analyzed in nephrectomy specimens from 227 advanced clear cell RCC (ccRCC) and 42 non-clear cell RCC (nccRCC) patients treated with targeted therapies including VEGF and mTOR inhibitors. Biomarker association with best overall response (BOR), progression-free survival (PFS), and overall survival (OS) were evaluated using multivariable modeling.

Temporal Trends in Clinical Evidence of 5-Year Survival Within Electronic Health Records Among Patients With Early-Stage Colon Cancer Managed With Laparoscopy-Assisted Colectomy vs Open Colectomy.

Importance: Temporal shifts in clinical knowledge and practice need to be adjusted for in treatment outcome assessment in clinical evidence.

Objective: To use electronic health record (EHR) data to (1) assess the temporal trends in treatment decisions and patient outcomes and (2) emulate a randomized clinical trial (RCT) using EHR data with proper adjustment for temporal trends.

Design, Setting, And Participants: The Clinical Outcomes of Surgical Therapy (COST) Study Group Trial assessing overall survival of patients with stages I to III early-stage colon cancer was chosen as the target trial.

A Thematic Analysis of Students' Perceptions and Experiences of Bullying in UK Higher Education.

Bullying in higher education (HE) has been relatively under-researched; despite its likely prevalence and impact on student wellbeing there is scant understanding of students' lived experiences of bullying. We conducted online and physical focus groups with UK HE students (40 undergraduates from 17 UK universities, mean age: 22), exploring their perceptions and experiences of bullying at university. Thematic analysis was used to identify key issues, specifically 1) the importance of a power imbalance and perpetuation of existing systemic inequality in a HE context; 2) bullying in HE is motivated by attainment of social and personal gains; 3) the tactics used to bully in HE resemble those seen in other contexts, but may be more nuanced; 4) bullying can be minimised and justified within HE, leading to its continued prevalence.

Primary-secondary school transition under Covid-19: Exploring the perceptions and experiences of children, parents/guardians, and teachers.

The transition from primary to secondary school is a major life event for eleven-year-old children in the United Kingdom, where they face simultaneous changes. Following the outbreak of Covid-19, transfer children face additional uncertainty on top of this. Negotiation of the multiple challenges, combined with the reduced support associated with Covid-19, could have a negative impact on children's school adjustment and mental health.

The Early Humor Survey (EHS): A reliable parent-report measure of humor development for 1- to 47-month-olds.

We created a 20-item parent-report measure of humor development from 1 to 47 months: the Early Humor Survey (EHS). We developed the EHS with Study 1 (N = 219) using exploratory factor analysis, demonstrating the EHS works with 1- to 47-month-olds with excellent reliability and a strong correlation with age, showing its developmental trajectory. We replicated the EHS with Study 2 (N = 587), revealing a one-factor structure, showing excellent reliability, and replicating a strong correlation with age.

Replication of Oncology Randomized Trial Results using Swedish Registry Real World-Data: A Feasibility Study.

Nationwide healthcare registries are potential important real-world data (RWD) sources for assessing drug effectiveness in oncology. However, it is unclear whether registry-derived RWD are suitable for clinical development. In this study, we replicate results from the comparator arm of two previously published oncology randomized controlled trials (RCTs) using RWD from Swedish nationwide healthcare registries.

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.

Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.

Design, Setting, And Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin.

'You're in this world now': Students', teachers', and parents' experiences of school transition and how they feel it can be improved.

Background: Primary-secondary school transition is a major life event for 11-year-old children in the United Kingdom and can also be a stressful period for parents and teachers. However, most research focuses on the impact of transition on children's academic performance and social well-being and we have a limited understanding of their emotional experiences in the lead up to and during the transition, from the perspective of key stakeholders: students, parents, and teachers.

Aims: To explore transfer students', parents', and teachers' experiences in the lead up to and over the transition period, and how they feel it could be improved.

Longitudinal associations between younger children's humour styles and psychosocial adjustment.

Whilst a multitude of studies have examined links between different styles of humour and aspects of adjustment, longitudinal research is noticeably lacking. Following a study which identified bidirectional associations between humour styles and psychosocial adjustment in older children, the current research aimed to investigate these associations in younger children. In total, 413 children aged 8-11 years completed the humour styles questionnaire for younger children (HSQ-Y) alongside measures of psychosocial adjustment in both the autumn and the summer over the course of a school year.

"As a Parent You Become a Tiger": Parents Talking about Bullying at School.

Bullying at school can be a distressing experience for children. It is also likely to be distressing for their parents. In spite of this, research in the field of school bullying and peer victimisation has tended to overlook the experience of parents when their child is bullied.

Children's Understanding of Self-Focused Humor Styles.

It has been proposed that four main styles of humor exist, two which are thought to be adaptive (affiliative, self-enhancing) and two which are thought to be maladaptive (aggressive, self-defeating). Whilst the existence of these four humor styles has been supported in older children, it is suggested that for younger children, self-enhancing and self-defeating humor may develop at a later point. To investigate this further, the current research involved five semi-structured paired interviews with children aged eight to eleven years to explore the use and understanding of self-enhancing and self-defeating humor in this age group.

Longitudinal Associations Between Humor Styles and Psychosocial Adjustment in Adolescence.

This study assessed the concurrent and prospective associations between psychosocial adjustment and four humor styles, two of which are adaptive (affiliative, self-enhancing) and two maladaptive (aggressive, self-defeating). Participants were 1,234 adolescents (52% female) aged 11-13 years, drawn from six secondary schools in England. Self-reports of psychosocial adjustment (loneliness, depressive symptomatology, and self-esteem) and humor styles were collected at two time points (fall and summer).

Humor style similarity and difference in friendship dyads.

This study assessed the concurrent and prospective (fall to spring) associations between four different humor styles to assess the degree to which stable friendships are characterized by similarity, and to assess whether best friends' humor styles influence each other's later use of humor. Participants were aged 11-13 years, with 87 stable, reciprocal best friend dyads. Self-report assessments of humor styles were completed on both occasions.

Development of the Attitudes to Domestic Violence Questionnaire for Children and Adolescents.

To provide a more robust assessment of the effectiveness of a domestic abuse prevention education program, a questionnaire was developed to measure children's attitudes to domestic violence. The aim was to develop a short questionnaire that would be easy to use for practitioners but, at the same time, sensitive enough to pick up on subtle changes in young people's attitudes. We therefore chose to ask children about different situations in which they might be willing to condone domestic violence.

Does the gender of the bully/victim dyad and the type of bullying influence children's responses to a bullying incident?

Children's responses to bullying are context related; they will vary depending on the specific bullying episode. The aim of the present study was to explore whether children's responses to bullying vary depending on the gender of the bully and victim and the type of bullying portrayed. In total, 437 children aged 9-11 years from four primary schools in the UK took part in the study.

Gender differences in the relationships between bullying at school and unhealthy eating and shape-related attitudes and behaviours.

BACKGROUND. Previous research has found links between being a victim of bullying and reporting more unhealthy eating behaviours and cognitions, particularly in girls. However, little is known about the factors that might mediate these relationships.

The relation between trust beliefs and loneliness during early childhood, middle childhood, and adulthood.

Four studies examined the relation between trust and loneliness. Studies 1, 2, and 3 showed that trust beliefs negatively predicted changes in loneliness during early childhood (5-7 years), middle childhood (9-11 years), and young adulthood (18-21 years). Structural equation modeling yielded support for the hypothesis that the relation between trust beliefs and loneliness was mediated, in part, by social disengagement, which varied by age and gender.

The association between adolescents' beliefs in a just world and their attitudes to victims of bullying.

Background: Research which has investigated children's attitudes to bullying has found that the majority of children display anti-bullying attitudes. However, a small minority of children do appear to admire the bully and lack sympathy for victims of bullying. The just world belief theory has received a great deal of attention in recent years with evidence emerging in support of a two-dimensional model distinguishing between beliefs in a just world (BJW) for self and BJW for others.

Global and physical self-esteem and body dissatisfaction as mediators of the relationship between weight status and being a victim of bullying.

Research has found evidence of a link between being overweight or obese and bullying/peer victimisation, and also between obesity and adjustment problems such as low self-esteem and body dissatisfaction. Studies have also found that adjustment problems can put children at an increased risk of being bullied over time. However, to date the factors that place overweight or obese children at risk of being bullied have been poorly elucidated.

Longitudinal associations between submissive/nonassertive social behavior and different types of peer victimization.

Previous research, primarily in North America, has found that submissive and nonassertive behaviors are associated with peer victimization during childhood. A limitation of this work has been the failure to examine the relationships between such behaviors and different types of peer victimization. To overcome this weakness, we developed an inventory to assess the bidirectional longitudinal associations between three different types of victimization and submissive/nonassertive social behavior.

Cross-sectional and longitudinal relations among children's trust beliefs, psychological maladjustment and social relationships: are very high as well as very low trusting children at risk?

Four hundred and thirty-four children enrolled in school years 5 and 6 in the United Kingdom were administered measures of trust beliefs in peers/best friends and psychosocial functioning (internalized maladjustment, self-perceived social acceptance, social preference, and social exclusion) across an 8-month period (mean age = 9 years-9 months at Time 1). The relation between children's trust beliefs in peers or trust beliefs within best friend dyads and measures of psychosocial functioning conformed to a quadratic pattern. Compared to children in the middle range of trust beliefs, children with very low trust beliefs and those with very high trust beliefs in peers and/or within best friend dyads displayed higher internalized maladjustment, lower self-perceived social acceptance, higher social exclusion, and lower social preference.

The social skills problems of victims of bullying: self, peer and teacher perceptions.

Background: A small number of prior studies have found that victims of school bullying tend to exhibit poor social skills. Few of these have examined this issue from multiple perspectives, and there has been a focus on a restricted range of social skills.

Aims: To determine the extent to which self, peers, and teachers regard victims as having poorer social skills than non-victims across 20 behaviours/competencies.

Cross-sectional and longitudinal relations among peer-reported trustworthiness, social relationships, and psychological adjustment in children and early adolescents from the United Kingdom and Canada.

Trustworthiness was examined in children and early adolescents from two countries. In Study 1,505 children in the fifth and sixth school years in the United Kingdom (mean age = 9 years 7 months) were tested across an 8-month period. In Study 2,350 sixth- through eighth-grade Canadian children and early adolescents (mean age = 12 years 11 months) were tested across a 1-year period.

Response inhibition can affect reaction time to abrupt-onset visual displays.

Reaction time (RT) to abrupt-onset stimuli has been widely used for more than a century to measure the duration of perceptuo-cognitive and motor processes [Donders, 1868/1969 Attention and Performance II (1969 Acta Psychologica 30 412-431)]. A complicating factor with the RT method is that of response withholding, or response inhibition (RI). The occurrence of RI (under this or other names) has been widely discussed in relation to studies of motor processes but has been largely ignored in relation to studies of perceptuo-cognitive processes.