Publications by authors named "Claire Deckers"
Neurobiol Stress
March 2024
Article Synopsis
- Astrocytes play a crucial role in regulating glutamatergic signaling, and their shape can change based on environmental factors, but the impact of early life experiences on their morphology is still not well understood.
- In a study using a postnatal resource scarcity model in rats, it was found that limited bedding and nesting (LBN) can enhance maternal behaviors and lead to greater resilience against addiction behaviors in adulthood, which involves changes in the medial orbitofrontal and medial prefrontal cortices.
- The research indicated that LBN exposure results in increased size of astrocytes in these brain regions for both male and female rats, with sex-specific transcriptional changes impacting glutamatergic signaling, suggesting
Article Synopsis
- Astrocytes, which are star-shaped brain cells, play a crucial role in regulating glutamatergic signaling and their structure can change based on environmental conditions.
- A study used a method called limited bedding and nesting (LBN) in rats, finding that early life resource scarcity led to increased astrocyte size in specific brain areas related to decision-making and addiction in adulthood.
- The research identified sex-specific gene expression changes related to glutamatergic signaling that could explain how LBN affects astrocyte morphology, suggesting that early resource deprivation can have significant long-term effects on brain function.
