Publications by authors named "Claire De Moreuil"
Article Synopsis
- Systemic sclerosis (SSc) is a complicated disease with various manifestations, making it hard to manage, but autoantibodies may help identify different patient groups and their underlying mechanisms.
- A study of 206 SSc patients used antibody status (ACA and SCL70) and various biological analyses to explore differences between groups.
- Results showed that SCL70-positive patients had more severe symptoms and unique biological profiles, while ACA-positive patients had a different set of immune and metabolic features, highlighting the importance of serological status in understanding and treating the disease.
Article Synopsis
- - Vasculo-placental disorders are pregnancy complications arising from issues with the placenta's blood vessels, such as pre-eclampsia, HELLP syndrome, and stillbirth faced due to vascular problems.
- - Pre-eclampsia in severe cases warrants testing for antiphospholipid syndrome (APS) and examining the placenta afterwards can reveal various anatomical and inflammatory issues that may contribute to complications like intrauterine growth retardation (IUGR).
- - A follow-up consultation two months post-delivery helps assess the causes of these disorders and provides guidance on managing future pregnancies and addressing cardiovascular health.
Article Synopsis
- Bleeding disorder of unknown cause (BDUC) is diagnosed after ruling out other causes, and this study analyzed data from 375 BDUC patients compared to 100 healthy controls.
- The findings revealed that BDUC patients had lower peak plasmin levels and clot density, indicating potential issues with clot structure, while still showing a higher potential for plasmin generation.
- A model including fibrinogen and plasmin generation parameters effectively distinguished BDUC patients from healthy controls, demonstrating the potential for predictive diagnostics in bleeding disorders.
Article Synopsis
- * In a study of 86 ITP patients and 78 healthy controls, findings showed that ITP patients had significantly slower clot lysis times and higher levels of plasminogen activator inhibitor-1 (PAI-1), while tissue plasminogen activator (tPA) levels were lower.
- * The results suggest that prolonged clot lysis time (CLT) and altered fibrinolysis mechanisms in ITP may contribute to thrombosis risk, with specifically higher tPA-PAI-1 complexes indicating potential
Article Synopsis
- Inactivation of the A20 gene is linked to a specific form of lymphoma and is studied in patients with haploinsufficiency of A20 (HA20), revealing immune system impacts.
- In a study of 34 HA20 patients, researchers found that the loss of one A20 gene copy leads to an increase in self-reactive lymphocyte receptors, often seen in lymphomas.
- The immune changes are driven by a feedback loop involving tumor necrosis factor (TNF), A20, and NF-κB, and can potentially be reversed by anti-TNF treatment, but may still lead to lymphoma development.
: Postpartum haemorrhage (PPH) is a frequent complication of childbirth that is difficult to predict. Predelivery coagulation biomarkers may help to guide preventive strategies. Our objective was to evaluate the association of predelivery haemostatic biomarkers with non-severe PPH.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to explore the characteristics of Systemic sclerosis (SSc) patients experiencing sicca symptoms, by analyzing major salivary glands through ultrasound, minor salivary gland biopsies, and clinical evaluations, while comparing these to patients with Sjögren's Disease (SjD) and other causes of sicca symptoms.
- A total of 60 SSc patients with sicca symptoms and additional groups including SSc patients without symptoms and SjD patients were examined, revealing that many SSc patients showed objective abnormalities in salivary gland function, even if they didn't report symptoms.
- The findings indicated that SjD-SSc patients had more severe salivary gland involvement compared to those with isolated conditions, highlighting the need for future
Objectives: Anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitides (AAV) are rare conditions characterized by inflammatory cell infiltration in small blood vessels, leading to tissue necrosis. While most patients with AAV present antibodies against either myeloperoxidase (MPO) or proteinase 3 (PR3), rare cases of dual positivity for both antibodies (DP-ANCA) have been reported, and their impact on the clinical picture remains unclear. The goal of this study was to investigate the clinical implications, phenotypic profiles and outcomes of patients with DP-ANCA.
View Article and Find Full Text PDFBackground: Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease. Given the inflammatory nature of ALS and the high number of ALS-related clinical circumstances (eg, prolonged immobilization and infections), patients with ALS may have a high risk of venous thromboembolism (VTE).
Objectives: To determine the annual incidence rate of VTE and the predictors of VTE in patients with ALS.
Background: Vascular phenotype is associated with a poor prognosis in systemic sclerosis (SSc). The identification of its risk factors could facilitate its early detection.
Objectives: To explore risk factors for a vascular phenotype of SSc, among them a history of pre-eclampsia.
Article Synopsis
- Some myopathies can cause dropped head or bent spine syndrome (DH/BS), but its significance in inflammatory myopathies (IM) hasn't been thoroughly explored.
- A study compared 49 patients with DH/BS related to IM to 98 control IM patients, finding that those with DH/BS were older and had more severe symptoms, including upper limb weakness, dysphagia, and muscle atrophy.
- The results suggest that DH/BS serves as a marker for the severity of IM and is often linked to complications related to systemic sclerosis, highlighting its clinical importance.
Background: Severe postpartum hemorrhage (PPH), defined as a blood loss ≥1000 mL, is associated with maternal morbidity and mortality.
Objectives: We aimed at characterizing coagulation properties of predelivery plasmas from pregnant women with thrombin generation assay and hemostatic biomarkers (plasminogen activator inhibitor-1, tissue factor [TF], and thrombomodulin).
Methods: A nested case-control study was conducted within the "Study of Biological Determinants of Bleeding Postpartum," a French prospective cohort study, in order to compare women with severe PPH (cases) and controls matched for age, body mass index, term, and mode of delivery.
Background: Postpartum hemorrhage is a major component of perinatal morbidity and mortality that affects young women worldwide and is still often unpredictable. Reducing the incidence of postpartum hemorrhage is a major health issue and identifying women at risk for postpartum hemorrhage is a key element in preventing this complication.
Objective: This study aimed to estimate postpartum hemorrhage prevalence after vaginal delivery and to identify postpartum hemorrhage risk factors.
Postpartum hemorrhage (PPH) is a leading cause of maternal morbi-mortality. Although obstetric risk factors are well described, the impact of predelivery hematologic and hemostatic biomarkers remains incompletely understood. In this systematic review, we aimed to summarize the available literature on the association between predelivery hemostatic biomarkers and PPH/severe PPH.
View Article and Find Full Text PDFObjective: Antiphospholipid syndrome (APS) is defined by the association of thromboembolic and/or obstetrical clinical manifestations and the presence of antiphospholipid antibodies. The objective of our study was to evaluate the impact of the triple-positive profile in a cohort of 204 APS patients.
Methods: We conducted a retrospective study, including patients with primary or secondary APS, meeting the Sydney criteria with at least one thrombotic and/or obstetrical complication.
Introduction: Antiphospholipid syndrome (APS) is an autoimmune disease characterised by thrombosis (arterial, venous or small vessel) or obstetrical events and persistent antiphospholipid antibodies (aPL), according to the Sydney classification criteria. Many studies have performed cluster analyses among patients with primary APS and associated autoimmune disease, but none has focused solely on primary APS. We aimed to perform a cluster analysis among patients with primary APS and asymptomatic aPL carriers without any autoimmune disease, to assess prognostic value.
View Article and Find Full Text PDF(1) Background: Placental histological lesions reported in relation with SARS-CoV-2 infection are various, with potential consequences such as fetal growth retardation, prematurity or stillbirth/neonatal death. We report here on a placental pathological association which could be specific for SARS-CoV-2 infection and associated with poor fetal outcome; (2) Methods: We collected all the placental pathological examinations performed in Brest University Hospital (France) since the beginning of COVID-19 pandemic with a known maternal SARS-CoV-2 infection and a poor pregnancy outcome. In these cases, we described the pathological lesions and we searched for these lesions in a large series of placentas collected and examined in the same institution before the SARS-CoV-2 pandemic; (3) Results: Three cases with severe fetal outcome (tardive abortion, prematurity, neonatal death), from the first to the third trimesters of pregnancy, were included.
View Article and Find Full Text PDFPostpartum hemorrhage (PPH) is one of the leading causes of maternal morbidity worldwide. This study aimed to develop and validate a predictive model for PPH after vaginal deliveries, based on routinely available clinical and biological data. The derivation monocentric cohort included pregnant women with vaginal delivery at Brest University Hospital (France) between April 2013 and May 2015.
View Article and Find Full Text PDFBackground: Hormonal exposure leads to an increased risk of venous thromboembolism (VTE) but the risk of VTE associated with assisted reproductive technology (ART) is not clearly determined.
Methods: We searched in PubMed, EMBASE, Web of Science, and the Cochrane Library databases and identified all relevant articles published up to February 1, 2021. The primary objective was to determine the frequency of VTE associated with ART.
Characterisation of a high-risk profile for maternal thrombotic and severe haemorrhagic complications in pregnant women with antiphospholipid syndrome in France (GR2): a multicentre, prospective, observational study.
Lancet Rheumatol
December 2022
Background: Prospective data about the risks of thrombotic and severe haemorrhagic complications during pregnancy and post partum are unavailable for women with antiphospholipid syndrome. We aimed to assess thrombotic and haemorrhagic events in a prospective cohort of pregnant women with antiphospholipid syndrome.
Methods: This multicentre, prospective, observational study was done at 76 centres in France.
Objective: Determine clinical risk factors for vasculo-placental disorders in singleton pregnancies.
Design: Prospective case-control study nested in HEMOTHEPP French cohort.
Setting: Women delivered between June, 2015 and January, 2019 in any maternity ward of Finistère.
After first episodes of venous thromboembolism (VTE), patients are at increased risk of recurrent VTE and arterial thrombotic events (ATE) compared with the general population, two disorders that are influenced by anticoagulation. However, risk factors of these conditions occurring during and after anticoagulation are little described. Using cause-specific hazard regression models, we aimed to determine risk factors of the composite outcome recurrent VTE/ATE, and separately recurrent VTE or ATE, during and after anticoagulation in patients with first episodes of VTE from a prospective cohort.
View Article and Find Full Text PDFArticle Synopsis
- Hereditary angioedema (HAE) is a serious condition causing unpredictable swelling attacks, and over the past decade, new treatments for long-term prophylaxis (LTP) have emerged based on a better understanding of its biology.
- A study conducted in France in 2020 surveyed physicians from 25 expert centers about their practices, treatments, and the unmet needs of HAE patients; ultimately focusing on 20 centers with active patient files.
- Of the 714 patients with C1 inhibitor deficiency, 59.2% were on LTP, but many still faced unmet needs related to treatment tolerability, efficacy, and cost; physicians expressed a desire for more effective, better-tolerated, and affordable therapies