A 24-h helpline for access to expert management advice for food allergy-related anaphylaxis in children: protocol for a pragmatic randomised controlled trial.

Objectives: Anaphylaxis is an important, potentially life-threatening paediatric emergency. It is responsible for considerable morbidity and, in some cases, death. Poor outcomes may be associated with an inability to differentiate between milder and potentially more severe reactions and an associated reluctance to administer self-injectable adrenaline.

Highly accurate prediction of food challenge outcome using routinely available clinical data.

Background: Serum specific IgE or skin prick tests are less useful at levels below accepted decision points.

Objectives: We sought to develop and validate a model to predict food challenge outcome by using routinely collected data in a diverse sample of children considered suitable for food challenge.

Methods: The proto-algorithm was generated by using a limited data set from 1 service (phase 1).