Chronic but not acute pharmacological activation of SERCA induces behavioral and neurochemical effects in male and female mice.

Intracellular calcium (Ca) homeostasis is a vital process to nerve cell survival and function with an intricate regulatory network. It is well established that the endoplasmic reticulum (ER) is a major intraneuronal Ca storage and that the sarco/endoplasmic reticulum (SR/ER) calcium (Ca)-ATPase (SERCA) pump is a key regulator of cytosolic Ca levels. SERCA pumps play a critical role in brain pathophysiology, thus SERCA comprises an emerging pharmacological target for the treatment of brain diseases.