SGLT2 inhibitors activate pantothenate kinase in the human heart.

Inhibitors of sodium glucose cotransporter-2 (SGLT2i) demonstrate strong symptomatic and mortality benefits in the treatment of heart failure but appear to do so independently of SGLT2. The relevant pharmacologic target of SGLT2i remains unclear. We show here that SGLT2i directly activate pantothenate kinase 1 (PANK1), the rate-limiting enzyme that initiates the conversion of pantothenate (vitamin B5) to coenzyme-A (CoA), an obligate co-factor for all major pathways of fuel use in the heart.

Vasohibin inhibition improves myocardial relaxation in a rat model of heart failure with preserved ejection fraction.

Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome associated with increased myocardial stiffness and cardiac filling abnormalities. Prior studies implicated increased α-tubulin detyrosination, which is catalyzed by the vasohibin enzymes, as a contributor to increased stabilization of the cardiomyocyte microtubule network (MTN) and stiffness in failing human hearts. We explored whether increased MTN detyrosination contributed to impaired diastolic function in the ZSF1 obese rat model of HFpEF and designed a small-molecule vasohibin inhibitor to ablate MTN detyrosination in vivo.

The Relationship Between the Isometric Squat and Stretch Shortening Cycle Function and Sprint Acceleration Performance in Hurling Players.

Brady, CJ, Harrison, AJ, Flanagan, EP, Haff, GG, and Comyns, TM. The relationship between the isometric squat and stretch shortening cycle function and sprint acceleration performance in hurling players. J Strength Cond Res 38(6): e288-e298, 2024-The primary aim was to examine the relationship between sprint acceleration performance and the performance tests: isometric squat (ISqT), countermovement jump (CMJ), and reactive strength index (RSI).

Dealing with digital paralysis: Surviving a cyberattack in a National Cancer center.

Introduction: Cyberattacks represent a growing threat for healthcare delivery globally. We assess the impact and implications of a cyberattack on a cancer center in Ireland.

Methods: On May 14th 2021 (day 0) Cork University Hospital (CUH) Cancer Center was involved in the first national healthcare ransomware attack in Ireland.

The Reliability and Magnitude of Time-Dependent Force-Time Characteristics During the Isometric Midthigh Pull Are Affected by Both Testing Protocol and Analysis Choices.

Guppy, SN, Kotani, Y, Brady, CJ, Connolly, S, Comfort, P, and Haff, GG. Title: The reliability and magnitude of time-dependent force-time characteristics during the isometric mid-thigh pull are impacted by both testing protocol and analysis choices. J Strength Cond Res 36(5): 1191-1199, 2022-This study aimed to investigate whether the use of short-duration (SHORT) isometric midthigh pull (IMTP) trials resulted in greater reliability and magnitude of time-dependent force-time characteristics than traditionally performed IMTP trials (TRAD).

A comparison of manual and automatic force-onset identification methodologies and their effect on force-time characteristics in the isometric midthigh pull.

The aim of this study was to assess the agreement of three different automated methods of identifying force-onset (40 N, 5 SDs, and 3 SDs) with manual identification, during the isometric mid-thigh pull (IMTP). Fourteen resistance-trained participants with >6 months experience training with the power clean volunteered to take part. After three familiarisation sessions, the participants performed five maximal IMTPs separated by 1 min of rest.

Assessing the accuracy of conventional gadolinium-enhanced breast MRI in measuring the nodal response to neoadjuvant chemotherapy (NAC) in breast cancer.

Management of the axilla in the era of neoadjuvant chemotherapy for breast cancer is evolving. The aim of this study is to determine if conventional gadolinium-enhanced breast MRI can aid in evaluation of the response to neoadjuvant chemotherapy in the axilla. A retrospective review of a prospectively maintained database of patients undergoing neoadjuvant chemotherapy for breast cancer was performed.

Effect of Altering Body Posture and Barbell Position on the Within-Session Reliability and Magnitude of Force-Time Curve Characteristics in the Isometric Midthigh Pull.

Guppy, SN, Brady, CJ, Kotani, Y, Stone, MH, Medic, N, and Haff, GG. Effect of altering body posture and barbell position on the within-session reliability and magnitude of force-time curve characteristics in the isometric midthigh pull. J Strength Cond Res 33(12): 3252-3262, 2019-A large degree of variation in the position used during isometric midthigh pull (IMTP) testing and conflicting results of the effects of these changes can be found in the literature.

The Relationship Between Isometric Strength and Sprint Acceleration in Sprinters.

Purpose: To examine the relationships between the isometric midthigh pull (IMTP), isometric squat (ISqT), and sprint acceleration performance in track-and-field sprinters and to determine whether there are differences between men and women.

Methods: Fifteen male and 10 female sprinters performed 3 maximal-effort IMTPs, ISqTs, and 3 × 30-m sprints from blocks.

Results: Among the men, the results showed significant negative correlations between IMTP and ISqT peak force; relative peak force; force at 100, 150, and 200 ms; rate of force development (0-150 and 0-200 ms); and impulse (0-200 ms) and 0- to 5-m time (r = -.

Effect of Attentional Focus Strategies on the Biomechanical Performance of the Drop Jump.

Comyns, TM, Brady, CJ, and Molloy, J. Effect of attentional focus strategies on the biomechanical performance of the drop jump. J Strength Cond Res 33(3): 626-632, 2019-Motor performance can be influenced by focusing an athlete's attention through the use of verbal instructions.

The Effect of Altering Body Posture and Barbell Position on the Between-Session Reliability of Force-Time Curve Characteristics in the Isometric Mid-Thigh Pull.

Seventeen strength and power athletes ( = 11 males, 6 females; height: 177.5 ± 7.0 cm, 165.

A review of the reliability of biomechanical variables produced during the isometric mid-thigh pull and isometric squat and the reporting of normative data.

The use of isometric strength testing, particularly the isometric mid-thigh pull (IMTP) has increased dramatically over the last decade. The IMTP and isometric squat (ISqT) provide one aspect of performance monitoring with variables such as peak force and rate of force development being derived from the force-time curve. The reliability of some of these variables is conflicting in the literature, and the reporting of the reliability is not standardised across the research.

A Comparison of the Isometric Midthigh Pull and Isometric Squat: Intraday Reliability, Usefulness, and the Magnitude of Difference Between Tests.

Purpose: To examine the reliability and usefulness of the isometric midthigh pull (IMTP) and isometric squat (ISqT) performed at the same knee and hip angles. The scores produced in each test were compared to determine the magnitude of differences between tests.

Methods: Twenty-six male and female athletes (age, 23.

The scale and nature of Viking settlement in Ireland from Y-chromosome admixture analysis.

The Vikings (or Norse) played a prominent role in Irish history but, despite this, their genetic legacy in Ireland, which may provide insights into the nature and scale of their immigration, is largely unexplored. Irish surnames, some of which are thought to have Norse roots, are paternally inherited in a similar manner to Y-chromosomes. The correspondence of Scandinavian patrilineal ancestry in a cohort of Irish men bearing surnames of putative Norse origin was examined using both slow mutating unique event polymorphisms and relatively rapidly changing short tandem repeat Y-chromosome markers.

Inflammation of the respiratory tract is associated with CCL28 and CCR10 expression in a murine model of allergic asthma.

Mouse models and in vitro cell culture were used to examine airway expression of the mucosal chemokine CCL28. Low levels of constitutively expressed mRNA were observed in transformed murine epithelial cells, but high levels could be induced by stimulation. Cytokines that signal through NF-kappaB, including IL-1beta and TNF-alpha or via JAK-STAT pathway including oncostatin M induced CCL28 in airway epithelial cells in vitro.

Human papillomavirus type 16 E6 variants in cervical carcinoma: relationship to host genetic factors and clinical parameters.

Infection with human papillomavirus type 16 (HPV-16) confers a high risk for the development of cervical neoplasia. Variants of this virus may interact differentially with host genetic factors, possibly altering the disease course. Thus, HPV-16 E6 variants may differ in their ability to degrade p53 whereas the polymorphic p53 alleles may provide more or less susceptible substrates for the viral oncogene product.