A systematic evaluation of five different image-derived input functions for the clinical implementation of F-NaF bone PET/CT in patients with chronic kidney disease-mineral and bone disorder.

Introduction: The aim of this study was to investigate the impact of the use of varying input parameters on resulting bone plasma clearance ( ) and other kinetic modelling parameters in a group of patients with chronic kidney disease-mineral and bone disorder (CKD-MBD).

Methods: Raw PET/CT data and blood data were systematically analyzed using five different VOIs for the input functions in the left ventricle and in the thoracic aorta. Standardized VOIs were placed in four thoracic vertebrae and the results pooled and averaged.

Reliability of rubidium-82 PET/CT for renal perfusion determination in healthy subjects.

Background: Changes in renal perfusion may play a pathophysiological role in hypertension and kidney disease, however to date, no method for renal blood flow (RBF) determination in humans has been implemented in clinical practice. In a previous study, we demonstrated that estimation of renal perfusion based on a single positron emission tomography/computed tomography (PET/CT) scan with Rubidium-82 (Rb) is feasible and found an approximate 5% intra-assay coefficient of variation for both kidneys, indicative of a precise method.This study's aim was to determine the day-to day variation of Rb PET/CT and to test the method's ability to detect increased RBF induced by infusion of amino acids.

Estimation of renal perfusion based on measurement of rubidium-82 clearance by PET/CT scanning in healthy subjects.

Background: Changes in renal blood flow (RBF) may play a pathophysiological role in hypertension and kidney disease. However, RBF determination in humans has proven difficult. We aimed to confirm the feasibility of RBF estimation based on positron emission tomography/computed tomography (PET/CT) and rubidium-82 (Rb) using the abdominal aorta as input function in a 1-tissue compartment model.