Publications by authors named "Cladiu T Supuran"
Bioorg Med Chem
January 2017
Article Synopsis
- - A series of benzenesulfonamides featuring 1,3,4-trisubstituted-β-lactam structures were synthesized using sulfanilamide Schiff bases and ketenes via the Staudinger cycloaddition reaction.
- - The newly created compounds were tested for their ability to inhibit four human isoforms of the carbonic anhydrase enzyme, which plays roles in various health issues, showing strong inhibitory effects across all isoforms.
- - Notably, the lactam-sulfonamides exhibited excellent inhibition, particularly against hCA VII, an isoform linked to neuropathic pain, with inhibition constants (Ks) ranging from 0.68 to 9.1nM.
