Publications by authors named "Clabbers J"
Article Synopsis
- Pathogenic variants in the filaggrin (FLG) gene are linked to a higher risk of developing atopic dermatitis (AD), prompting this study to explore how these variants affect dupilumab treatment outcomes.
- A total of 285 adult patients with AD were assessed for FLG variants and treatment effectiveness using various measures at the start and after 16 and 52 weeks of treatment.
- The findings revealed that dupilumab's effectiveness was similar for patients with and without pathogenic FLG variants, but those with biallelic variants reported worse skin dryness and flaking over time compared to others.
Article Synopsis
- Acitretin, a common oral treatment for ichthyosis, requires extended contraceptive measures post-treatment, posing challenges for women of childbearing age; alitretinoin is suggested as a safer alternative that allows pregnancy one month after stopping the medication.
- A study involved nine women aged 19-31 with various ichthyosis types, treated with alitretinoin for 2-28 months, showing significant improvements in skin severity scores.
- Side effects were generally mild and reversible; literature search revealed that most previous studies on alitretinoin for ichthyosis also reported significant improvements, indicating its potential as a valuable treatment option.
Ichthyosis covers a wide spectrum of diseases affecting the cornification of the skin. In recent years, new advances in understanding the pathophysiology of ichthyosis have been made. This knowledge, combined with constant development of pathogenesis-based therapies, such as protein replacement therapy and gene therapy, are rather promising for patients with inherited skin diseases.
View Article and Find Full Text PDFAside from the typical respiratory symptoms resulting from an infection with SARS-CoV-2, there are reports of cutaneous lesions in patients diagnosed with a SARS-CoV-2 infection. There are reports of multiple groups of skin lesions presenting in different stages of this diagnosis. The most common reported groups are chilblains, vesicular eruptions, morbilliformexanthems, acute urticaria and livedo.
View Article and Find Full Text PDFPurpose: The objective of this sub-analysis of the BeCet study (NCT01136005) was to examine health-related quality of life (HRQoL) of patients experiencing dermatological adverse events (AEs) during the first 6 weeks of epidermal growth factor receptor inhibitor (EGFRI) treatment.
Methods: Patients (n = 85) treated with EGFRI completed five questionnaires during the first 6 weeks of treatment. 77 patients provided enough data for the sub-analysis.