Publications by authors named "Civan Islak"

Purpose: Patients with contralateral carotid artery occlusion (CCO) represent a subgroup of patients at risk for revascularization procedures. The choice of appropriate revascularization procedure (carotid endarterectomy (CEA) or carotid artery stenting (CAS)) in these patients is controversial. The aim of this study is to share the results of clinical and radiological follow-up after CAS in these patients and to contribute to the literature by evaluating the efficacy and safety of stenting.

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Article Synopsis
  • Crossing Y-stent-assisted coiling (CYSAC) is a promising method for treating challenging wide-neck bifurcation aneurysms, although it can be technically difficult.
  • A study involving 37 patients treated with Y-stent-assisted coiling using LVIS EVO stents showed that a significant majority (83.8%) achieved excellent occlusion immediately after treatment, with high success rates maintained over an average follow-up of nearly 33 months.
  • The researchers' "drill turn" technique for stent crossing was effective, leading to safe outcomes and stable occlusion rates, demonstrating the method's feasibility for treating these aneurysms.
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Objective: In 2022, arterioectatic spinal angiopathy (AESA) of childhood was reported as a fatal, progressive, multi-segment myelopathy associated with a unique form of non-inflammatory spinal angiopathy involving diffuse dilatation of the anterior spinal artery and cord congestion in children. In this study, we present four more cases of AESA, using early and long-term conventional imaging and flat detector computed tomography angiography (FDCTA) imaging to assess the probability of disease regression and prevent unnecessary interventions.

Methods: We retrospectively reviewed the clinical and radiological findings of four patients with AESA seen in two neuroradiology departments between 2014 and 2023.

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Background And Purpose: The optimal antiplatelet regimen after flow diverter treatment of cerebral aneurysms is still a matter of debate. A single antiplatelet therapy might be advantageous in determined clinical scenarios. This study evaluated the efficacy and safety of prasugrel single antiplatelet therapy versus aspirin and clopidogrel dual antiplatelet therapy.

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Background: Understanding the hemodynamics of an abdominal aortic aneurysm (AAA) is crucial for risk assessment and treatment planning. This study introduces a low-cost, patient-specific in vitro AAA model to investigate hemodynamics using particle image velocimetry (PIV) and flow-simulating circuit, validated through fluid-structure interaction (FSI) simulations.

Methods: In this study, 3D printing was employed to manufacture a flexible patient-specific AAA phantom using a lost-core casting technique.

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  • The treatment of brain arteriovenous malformation (bAVM) includes various methods like microsurgery and embolization, with complete obliteration rates that vary significantly based on the grade of the bAVM.
  • The study emphasizes the effectiveness of dynamic 3D roadmap technology during endovascular procedures, improving navigation of microcatheters and reducing the need for multiple 2D angiograms, which can lower radiation exposure.
  • No complications were reported in the 21 cases treated using this method, highlighting its safety and efficacy in achieving higher rates of complete obliteration during bAVM embolization.
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Background: The anterior communicating artery (AComm) region is the most common site of intracranial aneurysms, with increased rupture risk compared with other locations. Overall, flow diverters present as a safe and efficacious treatment for intracranial aneurysms, but there is paucity of data for their use in the treatment of unruptured AComm aneurysms. We present the largest multicentric analysis evaluating the outcomes of flow diverters in AComm aneurysm treatment.

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Objective: The aim of this study is to present the clinical and imaging findings of 16 patients with intraventricular pilocytic astrocytomas (PAs).

Methods: 16 patients with histopathological diagnosis of intraventricular PA between February 2016 and January 2022 were evaluated retrospectively. Imaging and clinical findings of the patients, as well as apparent diffusion coefficient (ADC) measurements were analyzed.

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  • Flow diverter (FD) devices are effective for treating wide-necked intracranial aneurysms, but concerns exist about the health of arterial branches obstructed by the stent.
  • A study followed 18 patients with jailed middle cerebral artery branches after FD treatment, finding that 65% of aneurysms were completely occluded after a median of 35 months.
  • Magnetic resonance perfusion (MRP) data showed notable perfusion changes in jailed branches, although they were not usually linked to clinical symptoms, suggesting FD treatment is generally safe.
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  • This study assessed the feasibility, safety, and effectiveness of Y-stent-assisted coiling (Y-SAC) with LEO Baby® stents for treating bifurcation aneurysms in patients from 2009 to 2019.
  • A total of 111 patients, primarily with incidental wide-necked aneurysms, were evaluated, achieving high immediate occlusion rates (95.5% complete closure) and maintaining these results at 6 months and over 2 years of follow-up for most cases.
  • The procedure was found to be safe with a low complication rate (4.8%), demonstrating Y-SAC as a reliable method for treating complex bifurcation aneurysms while keeping arterial structures intact.
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Background And Purpose: This study aimed to investigate the potential contribution of quantitative measurements of dural venous sinuses to the diagnosis of idiopathic intracranial hypertension (IIH) and the relationship between IIH and dural venous sinus dimensions on 3D post-gadolinium T1-weighted magnetic resonance (MR) images.

Material And Methods: A total of 129 individuals (57 IIH patients and 72 controls) who complained of headache and underwent both magnetic resonance venography (MRV) and precontrast/postcontrast 3D T1-weighted MR imaging between 2018 and 2021 were included in this retrospective study. Dural venous sinus and jugular vein diameters were measured in all cases using post-gadolinium 3D T1 TFE images.

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Craniocervical dissection is one of the most common causes of stroke in children. Although the most common cause of dissection is trauma, spontaneous dissections in which no cause can be revealed may also occur. The diagnosis of this type of dissection in children can be challenging with the preferred non-invasive imaging methods (MRA, CTA).

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Flow diversion is increasingly used as an endovascular treatment for intracranial aneurysms. In this retrospective multicenter study, we analyzed the safety and efficacy of the treatment of intracranial, unruptured, or previously treated but recanalized aneurysms using Flow Re-Direction Endoluminal Device (FRED) Jr with emphasis on midterm results. Clinical and radiological records of 150 patients harboring 159 aneurysms treated with FRED Jr at six centers between October 2014 and February 2020 were reviewed and consecutively included.

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Background: Anterior falcotentorial junction dural arteriovenous fistulas (AFDAVFs) are the most deeply located and most complex type of tentorial fistula due to their location and vascular anatomy. We aimed to make new angiographic definitions of AFDAVF nidus and functionality of the deep venous system of the brain and thereby provide a safer approach for endovascular treatment.

Methods: We retrospectively examined 18 patients with AFDAVF who received endovascular treatment at our neuroradiology department between June 2002 and May 2019.

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Purpose: Flow diverter stents are gaining wider use in the treatment of complex intracranial aneurysms; however, there are limited data on occlusion and complication rates of flow diverters in very large and giant aneurysms. This study assessed the safety and efficacy of flow redirection endoluminal device (FRED) and FRED Jr. stents in aneurysms ≥ 20 mm.

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Purpose: The aim of this study is to demonstrate the diagnostic effect of VWI in differentiating PACNS from other vasculopathies and its role in post-treatment follow-up in PACNS patients in this study.

Methods: In this prospective study, we included patients with clinical suspicion of PACNS who presented with new-onset ischemic events and had significant intracranial large vessel stenosis on DSA or MRA. VWI was performed on all patients.

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Background: Indications for flow diversion stent (FDS) treatment are expanding. However, there is still a lack of evidence for the long-term outcome in distally located aneurysms in the M2 segment of the middle cerebral artery (MCA) and beyond.

Methods: Consecutive subjects (from June 2013 to August 2020) with MCA aneurysms in the M2 segment or beyond treated with FDS were reviewed retrospectively.

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Background And Purpose: The transverse sinus (TS) is a frequent location of cerebral venous thrombosis. However, unilateral TS hypoplasia is a frequent variation and radiological imaging pitfall in the diagnosis because it may mimic unilateral TS thrombosis. The purpose of this study is to find a cutoff value for bilateral jugular foramen (JF) diameter ratios on magnetic resonance imaging (MRI) for differentiating TS thrombosis from TS hypoplasia.

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Purpose: We report a multicenter experience using endovascular embolization as the first line approach for treatment of anterior cranial fossa (ACF) dural arteriovenous fistula (DAVF).

Methods: All patients with DAVFs located in the anterior cranial fossa who were treated with endovascular technique as a first line approach were included. Demographics, clinical presentation, angioarchitecture, strategy, complications, immediate angiographic, and follow-up results were included in the analysis.

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Background: Dual antiplatelet therapy consisting of aspirin and clopidogrel is the standard of care for neurointerventional stenting and flow diversion. Platelet function testing has been increasingly performed to identify patients with a hypo- or hyper-response to clopidogrel. Ticagrelor has been a popular alternative antiplatelet agent for such patients.

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Article Synopsis
  • - The study compared two endovascular flow diverters, the Pipeline Embolization Device (PED) and Flow Redirection Intraluminal Device (FRED), focusing on their effectiveness in treating posterior circulation aneurysms.
  • - Using a matched cohort design, researchers collected data from 375 treated aneurysms and found no significant differences in aneurysm occlusion or complication rates between the two devices.
  • - However, FRED demonstrated a higher rate of favorable functional outcomes (100% vs. 87.9%) compared to PED, suggesting the need for further research into these functional differences.
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  • Intrathecal gadolinium-enhanced MR cisternography (IGE-MRC) is an effective tool for detecting cerebrospinal fluid (CSF) leaks in patients, particularly those with otorhinorrhea.
  • A study reviewed 85 patients with suspected CSF leaks from 2017 to 2019, showing that a significant number underwent surgery, and most reported no serious complications following the procedure.
  • The findings support IGE-MRC as a safe and minimally invasive method for assessing CSF leakage, highlighting its diagnostic performance and the overall well-being of patients post-evaluation.
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Background: Design of flow-diverter stents for flexibility, tractability, and low profile limits their radiopacity on conventional digital subtraction angiography. Cone-beam computed tomography (CBCT) offers higher spatial resolution for the evaluation of flow-diverter stents. However, CBCT requires optimal dilution and timing of contrast medium for simultaneous visualization of the stent, arterial lumen, and vessel wall.

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