Publications by authors named "Citlali Gutierrez"
Inhibition of amyloid β (Aβ) aggregation and cholinesterase activity are two major therapeutic targets for Alzheimer's disease (AD). Multifunctional Molecules (MFMs) specifically designed to address other contributing factors, such as metal ion induced abnormalities, oxidative stress, toxic Aβ aggregates etc. are very much required.
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- * A series of benzothiazole-based Ir(III) complexes (HN-1 to HN-8) have shown promising abilities to inhibit Aβ aggregation and increase fluorescence when interacting with Aβ in living cells.
- * Four of these complexes (HN-1, HN-2, HN-3, and HN-8) successfully cross the blood-brain barrier and can stain amyloid plaques in mouse models of Alzheimer's after treatment, indicating their potential as therapeutic and diagnostic agents.