Left-handedness is statistically linked to lifetime experimentation with illicit drugs.

Handedness has been linked to an enhanced risk of alcohol abuse, while less is known about other drugs. A convenience sample of 1004 male and female Italian participants (females=58%) from the general community (18 to 65 years old: average age = 30; standard deviation = 10, median = 25) was asked about: handedness (preference in writing); lifetime use of alcohol, tobacco, and illicit drugs; levels of psychological distress, as measured by the General Health Questionnaire (GHQ); and levels of delusion proneness, as measured by the Peters et al. Delusions Inventory (PDI).

Mixed-handedness is associated with the reporting of psychotic-like beliefs in a non-clinical Italian sample.

Atypical handedness has been repeatedly reported in schizophrenia, with quantitative review of evidence showing an increase of non-right-handedness in patients diagnosed with schizophrenia. Mixed-handedness is also higher among non-clinical people scoring high on questionnaires aimed at measuring psychosis-proneness. However, the greatest part of information on non-clinical samples came from samples collected in North America or in the UK: differences by countries in the socio-cultural pressure to use the right hand could influence the results.