Evaluation of plasma cortisol during fasting test in patients with endogenous hyperinsulinemic hypoglycemia. Fifteen years experience.

Background: Endogenous hyperinsulinemic hypoglycemia (EHH) is a rare clinical condition. The aim of this study was to evaluate baseline plasma cortisol concentration and its concentration during hypoglycemic crisis in fasting tests (FT) performed in our center. Secondarily, the aim was to establish the relationship between baseline cortisol and the time of evolution of EHH.

A Pragmatic Turn in the Study of Early Executive Functions by Object Use and Gestures. A Case Study from 8 to 17 Months of Age at a Nursery School.

The two first years of life are critical in the development of Executive Functions (EF). However, very little is known about their early manifestations, how they develop, how they relate to other psychological constructions or the status of other people's influence in this early development. The study of EFs has been carried out through standardised tasks, but some authors question their ecological validity and suggest an approach involving everyday situations and the challenges that children set for themselves.

The development of categorisation and conceptual thinking in early childhood: methods and limitations.

We present a systematic and qualitative review of academic literature on early conceptual development (0-24 months of age), with an emphasis on methodological aspects. The final sample of our review included 281 studies reported in 115 articles. The main aims of the article were four: first, to organise studies into sets according to methodological similarities and differences; second, to elaborate on the methodological procedures that characterise each set; third, to circumscribe the empirical indicators that different sets of studies consider as proof of the existence of concepts in early childhood; last, to identify methodological limitations and to propose possible ways to overcome them.

Getting away from the point: the emergence of ostensive gestures and their functions.

Within developmental psychology, pointing gestures have received a great deal of attention, while ostensive gestures have been overlooked in terms of their emergence and intentionality. In a longitudinal and micro-genetic study with six children at 9, 11, and 13 months of age, we codified gesture production of children within second-by-second data frames. We identified 480 instances of gestures and categorised whether they were of ostensive, ostensive-indexical, or indexical nature.

Musical dynamics in early triadic interactions: a case study.

Research of the last 30 years showed the importance of music for psychological development. Communicative musicality studies described musical organisations in dyadic interactions (adult-baby). However, other perspectives proposed that, from the beginning of life, there are early triadic interactions (adult-object-baby) that should also be analysed.

Early Understanding of Cardinal Number Value: Semiotic, Social, and Pragmatic Dimensions in a Case Study with a Child from 2 to 3 Years Old.

Studies on cardinality date back many years, and it remains a current research issue today. Indeed, despite the many findings on the topic, there is still controversy surrounding when and how children understand cardinality. The main studies on this understanding employs the "how many" question in situations involving the quantification of objects, analyzing the relationship between counting and cardinality.

Artificial Pancreas: Clinical Study in Latin America Without Premeal Insulin Boluses.

Background: Emerging therapies such as closed-loop (CL) glucose control, also known as artificial pancreas (AP) systems, have shown significant improvement in type 1 diabetes mellitus (T1DM) management. However, demanding patient intervention is still required, particularly at meal times. To reduce treatment burden, the automatic regulation of glucose (ARG) algorithm mitigates postprandial glucose excursions without feedforward insulin boluses.

Communicative Mediation by Adults in the Construction of Symbolic Uses by Infants.

Adult semiotic mediation in the origin and evolution of the first symbolic uses of objects by infants in contexts of triadic interactions was investigated. Six infant-parent dyads interacting together with ten objects were observed longitudinally from 9 to 15 months of age, with an interval of three months between each observation. The communicative mediators used by adults, in the form of demonstrations and ostensive gestures, decrease as infants grow up.

Rhythmic ostensive gestures: How adults facilitate infants' entrance into early triadic interactions.

For decades, the literature on the emergence of triadic interactions considers the end of the first year of life as the time when children become able to communicate with others intentionally about a referent. Prior to that, children only relate in dyads, either with someone else or with an object. However, several researchers claim that referents are not naturally given in human communication and that they need to be established in interaction with others.

The Rhythmic, Sonorous and Melodic Components of Adult-Child-Object Interactions Between 2 and 6 Months Old.

Adults mediate the relationship between material reality and children, according to functional units of cultural relevance. This paper explores early development of semiotic systems in infants, analyzing rhythmic, sonorous and melodic components, which enable adult-child interaction with and about objects. The triads (with sonorous and non-sonorous objects) was studied longitudinally at age 2, 4 and 6 months.

The connection between language and the world: a paradox of the linguistic turn?

Alex Gillespie and Flora Cornish draw on the dialogic turn as they consider that, in order to interpret the meaning of an utterance, it is necessary to emphasize its contextual nature. Among other aspects, they address what context is and what is being done while speaking. Taking these two issues as point of departure, it is worth pondering on (1) what revolves around language and what the status of nonlinguistic semiotic systems is for the philosophers of language, (2) Umberto Eco's critique of the Philosophy of Language, which has not problematized the pre-linguistic relationship with things, and (3) how ontogenesis may shed light on this scheme where linguistic and nonlinguistic aspects are inevitably interrelated.

First symbols in a girl with Down syndrome: a longitudinal study from 12 to 18 months.

Symbolic uses of objects originate in communicative and triadic contexts (adult-child-object). In this longitudinal study we explore the emergence and development of the first symbolic uses in triadic interaction contexts in a girl with Down syndrome between 12 and 18-months of age. We conducted five sessions of video recording, at 12, 13½, 15, 16½, and 18 months chronological age.

Do private gestures have a self-regulatory function? A case study.

One of the most fascinating phenomena in early development is that babies not only understand signs others direct to them and later use them to communicate with others, but they also come to direct the same signs towards themselves in a private way. Private gestures become "tools of thought". There is a considerable literature about private language, but almost nothing about private gestures.