Publications by authors named "Cinti F"

Omega-3 fatty acids reduce triglycerides and have several positive effects on different organs and systems. They are also found in the plasma membrane in variable amounts in relation to genetics and diet. However, it is still unclear whether omega-3 supplementation can reduce the occurrence of major cardiovascular events (MACEs).

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Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have emerged as important agents for the treatment of type 2 diabetes mellitus (T2DM). SGLT2 inhibitors have been associated with improved cardiovascular outcomes, not only through their immediate hemodynamic effects-such as glycosuria and (at least temporary) increased natriuresis-but also due to their multifaceted impact on metabolism. Recently, studies have also focused on the effects of SGLT2 inhibitors on adipose tissue.

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The effects of frustration on extended supersolid states is a largely unexplored subject in the realm of cold-atom systems. In this work, we explore the impact of quasicrystalline lattices on the supersolid phases of dipolar bosons. Our findings reveal that weak quasicrystalline lattices can induce a variety of modulated phases, merging the inherent solid pattern with a quasiperiodic decoration induced by the external potential.

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Purpose: Physical exercise is a key component in the treatment of type 2 diabetes and plays an important role in maintaining a healthy glucose metabolism even in healthy subjects. To date, no studies have investigated the effect of a single bout of aerobic physical exercise on glucose metabolism in young, moderately active, healthy adults.

Methods: We performed an OGTT 7 days before and 24 h after a single bout of physical exercise, to evaluate 1-hour post-load plasma glucose and surrogate indexes of insulin sensitivity and insulin secretion.

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Discovering novel emergent behavior in quantum many-body systems is a main objective of contemporary research. In this Letter, we explore the effects on phases and phase transitions of the proximity to a Ruelle-Fisher instability, marking the transition to a collapsed state. To accomplish this, we study by quantum Monte Carlo simulations a two-dimensional system of soft-core bosons interacting through an isotropic finite-ranged attraction, with a parameter η describing its strength.

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Objectives: To describe the clinical features and oncologic outcome for cats with primary rib tumours.

Materials And Methods: Medical records for cats with surgically treated primary rib tumours from six veterinary referral centres were reviewed. Signalment, preoperative clinical signs, reconstruction technique, and surgical and oncologic outcome were retrieved from medical records or by telephone interview with owners and/or referring veterinarians.

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Background: Lynch syndrome (LS) is a genetic disease with increased risk of colorectal cancer and other malignancies. There are few reported cases of thyroid cancer in LS patients. The aim of this study is to investigate the presence of thyroid nodules in LS patients and to explore their association with the genetic features of the disease.

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Objectives: To investigate the use of endovascular gastrointestinal stapling devices to perform intestinal functional end-to-end stapled anastomosis in small dogs and cats.

Materials And Methods: Medical records of dogs (≤10 kg) and cats that underwent intestinal resection and functional end-to-end stapled anastomosis with an endovascular gastrointestinal anastomosis (endovascular-GIA) stapling device at five small animal referral centres between April 2014 and September 2023 were retrospectively reviewed. Data including clinical findings, surgical technique, histopathology and complications were collected.

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Aims: Chronic pancreatitis (CP) is - along with acute pancreatitis - the most frequent cause of diabetes of the exocrine pancreas (DEP). Although insulin deficiency is widely accepted as the major feature of DEP, it is still unclear whether diabetes associated with CP is characterized by additional or different functional defects of the insulin secretory machinery. To identify possible functional defects specifically induced by CP, we performed a cross-sectional study in individuals with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and diabetes mellitus (DM) comparing patients with and without CP (CP vs.

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The aim of this review is to discuss the several interconnections between thyroid autoimmunity and type 1 diabetes in terms of epidemiology, immunoserology, genetic predisposition, and pathogenic mechanisms. We will also analyze the impact of these conditions on both male and female fertility. A literature search was carried out using the MEDLINE/PubMed, Scopus, Google Scholar, ResearchGate, and Clinical Trials Registry databases with a combination of keywords.

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Objective: To evaluate the outcomes and complications of video-assisted thoracoscopic (VATS) treatment of chylothorax in cats.

Study Design: Multi-institutional retrospective study.

Animals: Fifteen client-owned cats.

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Objective: To report the perioperative outcome and complications in cats undergoing minimally invasive splenectomy.

Animals: 17 client-owned cats.

Methods: Perioperative data were collected from cats undergoing minimally invasive splenectomy from September 2010 to June 2023.

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Confinement can have a considerable effect on the behavior of particle systems and is therefore an effective way to discover new phenomena. A notable example is a system of identical bosons at low temperature under an external field mimicking an isotropic bubble trap, which constrains the particles to a portion of space close to a spherical surface. Using path integral Monte Carlo simulations, we examine the spatial structure and superfluid fraction in two emblematic cases.

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A 3 yr old spayed female Cavalier King Charles spaniel was referred for insidious ataxia and paraparesis. A thoracolumbar lesion was suspected. Computed tomography showed focal osteolysis of the vertebral body and pedicles of T5.

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Article Synopsis
  • - The study examined the effects of the SGLT-2 inhibitor dapagliflozin on epicardial adipose tissue (EAT) and glucose metabolism in type 2 diabetes patients with stable coronary artery disease.
  • - Dapagliflozin treatment resulted in a significant 19% reduction in EAT thickness and a 21.6% decrease in EAT glucose uptake compared to placebo after 4 weeks.
  • - These findings suggest that SGLT-2 inhibitors may benefit cardiovascular health by targeting specific fat deposits related to inflammation and metabolism.
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Objective: To describe the surgical management and outcome of dogs undergoing laparoscopic pancreatic mass resection (LPMR).

Study Design: Retrospective study.

Animals: Twelve client-owned dogs.

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Objectives: The objective was to report and compare the complications and recurrence rates of urethral prolapse in dogs when treated with urethropexy, resection and anastomosis or a combined surgical technique.

Study Design: Retrospective study.

Materials And Methods: A total of 86 dogs were identified from the medical records of 10 veterinary referral hospitals from February 2012 and October 2022.

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We study the low-temperature phases of interacting bosons on a two-dimensional quasicrystalline lattice. By means of numerically exact path integral Monte Carlo simulations, we show that for sufficiently weak interactions the system is a homogeneous Bose-Einstein condensate that develops density modulations for increasing filling factor. The simultaneous occurrence of sizeable condensate fraction and density modulation can be interpreted as the analogous, in a quasicrystalline lattice, of supersolid phases occurring in conventional periodic lattices.

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Objectives: To describe the clinical presentation, diagnostic findings, surgical treatment and outcome of dogs diagnosed with parotid duct ectasia.

Materials And Methods: Medical records of dogs diagnosed with parotid duct ectasia between 2010 and 2023 at six small animal referral hospitals were retrospectively reviewed. Outcome was assessed by contacting the owners or referring veterinarians.

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Article Synopsis
  • SGLT2 inhibitors like dapagliflozin have mixed results on plasma lipids, showing slight increases in HDL cholesterol but little evidence of improved HDL functionality; however, they are recognized for their cardiovascular protective roles.
  • A study with 16 patients examined how dapagliflozin affects nitric oxide (NO) production through HDL and its relation to myocardial flow reserve (MFR), finding no significant changes in HDL cholesterol or NO production between the dapagliflozin and placebo groups.
  • The results imply that the improvements in coronary microcirculation seen with dapagliflozin in patients with type 2 diabetes and coronary artery disease (CAD) may not be linked to changes in
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Type 2 diabetes mellitus (T2DM) is one of the most widespread diseases worldwide. Lifestyle interventions, including diet and physical activity (PA), are fundamental non-pharmacological components of T2DM therapy. Exercise interventions are strongly recommended for people with or at risk of developing or already with overt diabetes, but adherence to PA guidelines in this population is still challenging.

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Alginate-based beads containing a porous zeolite filler were developed as carriers of bioactive compounds with a hydrophobic nature, such as curcumin (Cur). Curcumin, a natural pigment extracted from the turmeric (Curcuma longa) plant, exhibits antioxidant, anti-inflammatory, anticarcinogenic, and antiviral properties. To enhance the bioavailability of the drug, curcumin needs to be encapsulated in a suitable carrier that improves its dispersibility and solubility.

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Objectives: The present study aimed to document the use of the wound infusion catheter (WIC) following a variety of surgical procedures in cats, investigating complications and risk factors associated with catheter placement or local anaesthetic (LA) administration.

Methods: A retrospective, multicentric study was performed. Medical databases of eight veterinary referral hospitals from 2010 to 2021 were searched to identify records of cats where WICs were used.

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