Publications by authors named "Cinthia Magalhaes Rodolphi"
Characterization of T and B cell epitopes in PvCyRPA by studying the naturally acquired immune response in Brazilian Amazon communities.
Sci Rep
November 2024
Article Synopsis
- Plasmodium vivax causes millions of malaria cases worldwide, highlighting the urgent need for effective vaccine development, especially given the lack of studies on specific vaccine candidates for this species.
- The merozoite protein CyRPA has shown promise as a vaccine candidate due to its essential role in the growth and invasion of P. falciparum, and preliminary studies suggest that PvCyRPA is better at providing protection compared to traditional malaria vaccine candidates.
- Research in Brazilian malaria-endemic areas indicates that PvCyRPA is immunogenic, eliciting a strong immune response with important B and T cell epitopes, supporting its potential inclusion in future malaria vaccine formulations targeting P. vivax
Lung Damage Induced by ANKA in Murine Model of Malarial Infection is Mitigated by Dietary Supplementation with DHA-Rich Omega-3.
ACS Infect Dis
October 2024
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe complications that can occur in infections caused by any species. Due to the high lethality rate and the lack of specific treatment for ALI/ARDS, studies aimed at understanding and searching for treatment strategies for such complications have been fundamental. Here, we investigated the protective role of dietary supplementation with DHA-rich fish oil against lung damage induced by ANKA in a murine model.
View Article and Find Full Text PDFDynamics of IgM and IgG Antibody Response Profile against Linear B-Cell Epitopes from Exoerythrocytic (CelTOS and TRAP) and Erythrocytic (CyRPA) Phases of : Follow-Up Study.
Antibodies (Basel)
August 2024
Malaria is a serious health problem worldwide affecting mainly children and socially vulnerable people. The biological particularities of , such as the ability to generate dormant liver stages, the rapid maturation of gametocytes, and the emergence of drug resistance, have contributed to difficulties in disease control. In this context, developing an effective vaccine has been considered a fundamental tool for the efficient control and/or elimination of vivax malaria.
View Article and Find Full Text PDFArticle Synopsis
- A study focused on malaria in the Americas highlights the need for a multi-antigen vaccine due to the complex life cycle of the malaria parasite.
- Researchers developed a chimeric recombinant protein called PvRMC-1, which was found to elicit immune responses in mice when formulated with different adjuvants.
- Results showed that while all formulations generated immune responses, Stimune and AddaVax were more effective in promoting both cellular and humoral immunity compared to aluminum hydroxide, suggesting that PvRMC-1 could be a strong candidate for further vaccine development.
DHA-rich fish oil plays a protective role against experimental cerebral malaria by controlling inflammatory and mechanical events from infection.
J Nutr Biochem
January 2024
Every year, thousands of children, particularly those under 5 years old, die because of cerebral malaria (CM). Following conventional treatment, approximately 25% of surviving individuals have lifelong severe neurocognitive sequelae. Therefore, improved conventional therapies or effective alternative therapies that prevent the severe infection are crucial.
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