Publications by authors named "Cinthia I Drachenberg"
Article Synopsis
- * In patients with morbid obesity and HFpEF, there are notable changes in heart muscle cells, including disrupted calcium response, altered gene expression, and cellular structure issues.
- * Advanced imaging techniques revealed severe damage to heart muscle, particularly in the most obese patients, including mitochondrial dysfunction and reduced fatty acid processing, independent of diabetes.
Background: Due to lack of treatment options for early acute allograft dysfunction in the presence of tubular-interstitial injury without histological features of rejection, kidney transplant recipients are often treated with sirolimus-based therapy to prevent cumulative calcineurin inhibitor exposure and to prevent premature graft failure.
Methods: We analyzed transplant recipients treated with sirolimus-based (n = 220) compared with continued tacrolimus-based (n = 276) immunosuppression in recipients of early-onset graft dysfunction (threatened allograft) with the use of propensity score-based inverse probability treatment weighted models to balance for potential confounding by indication between 2 nonrandomized groups.
Results: Weighted odds for death-censored graft failure (odds ratio [OR], 1.
Background: Composite tissue allotransplantation may have different immunosuppressive requirements and manifest different complications compared with solid organ transplantation. We developed a non-human primate facial composite tissue allotransplantation model to investigate strategies to achieve prolonged graft survival and immunologic responses unique to these allografts.
Methods: Composite facial subunits consisting of skin, muscle, and bone were heterotopically transplanted to mixed lymphocyte reaction-mismatched Cynomolgus macaques.