Publications by authors named "Cinthia D Coria-Lucero"
Late-Onset Caloric Restriction Improves Cognitive Performance and Restores Circadian Patterns of Neurotrophic, Clock, and Epigenetic Factors in the Hippocampus of Old Male Rats.
J Gerontol A Biol Sci Med Sci
December 2024
Article Synopsis
- Aging leads to functional decline and cognitive impairment, but caloric restriction (CR) can help delay these effects and improve cognitive function in older adults.
- There is a connection between memory, learning, and the circadian clock, which indicates that timing and regulation are essential for cognitive processes.
- Research showed that late-onset CR restored circadian rhythms and improved cognitive abilities in aging rats, suggesting that lifestyle changes like CR could preserve brain health as we age.
Aging abolishes circadian rhythms and disrupts temporal organization of antioxidant-prooxidant status, endogenous clock activity and neurotrophin gene expression in the rat temporal cortex.
Neuroscience
November 2024
Disruption of circadian rhythms contributes to deficits in cognitive functions during aging. Up to date, the biochemical, molecular and chronobiological bases of such deterioration have not been completely elucidated. Here, we aim: 1) to investigate the endogenous nature of 24 h-rhythms of antioxidant defenses, oxidative stress, clocḱ's, and neurotrophic factors expression, in the rat temporal cortex (TC), and 2) to study the consequences of aging on the circadian organization of those factors.
View Article and Find Full Text PDFAging brain undergoes several changes leading to a decline in cognitive functions. Memory and learning-related genes such as Creb, Bdnf and its receptor TrkB, are expressed in different brain regions including prefrontal cortex. Those genes' proteins regulate a wide range of functions such as synaptic plasticity and long-term potentiation.
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