Publications by authors named "Cingeetham Vinod"
Article Synopsis
- Calcineurin, a calcium-dependent protein, is linked to inflammation in arteries and plaque formation in coronary artery disease (CAD).
- The study investigates the PPP3R1 gene polymorphism's association with serum calcineurin levels in CAD patients versus healthy controls, using ELISA and PCR-RFLP methods.
- Findings suggest that a specific genetic variation (5I/5D) correlates with higher serum calcineurin and increased risk of CAD, indicating its role in vascular inflammation and atherosclerosis.
Male breast cancer (MBC) is a rare and poorly studied disease that is a growing global health problem. Interestingly, both the molecular basis of MBC and its histological profile are often quite distinct from the far more prevalent female breast cancer, emphasizing the need for increased focus on MBC. Here, we present a case report of an MBC patient from India with a strong familial history of breast cancer.
View Article and Find Full Text PDFBackground: Evading the immune destruction and angiogenesis has been the two hallmarks of cancer. Interleukin-10 (IL-10) is a cytokine with immune suppressing (pro-tumorigenic) and anti-angiogenic (anti-tumorigenic) properties, thus making the role of IL-10 in tumorigenesis enigmatic. Previous studies have suggested a critical role of IL10 altered expression in complex process of tumor-microenvironment, co-evolution and tumorigenesis.
View Article and Find Full Text PDFTransformation growth factor β1 is a multipotent cytokine that mediates the development, differentiation, and neoplasm of the mammary gland. TGF β1 is known to exert both tumor suppressive and progressive effect at different stages of carcinogenesis. Several studies have shown the association of TGF β1 expression with breast cancer markers like estrogen receptor (ER), progesterone receptor (PR), and Her2/neu.
View Article and Find Full Text PDFPurpose: To evaluate the clinical, biochemical and cytogenetic analyses of a couple with reproductive failure.
Methods: A couple with a history of recurrent pregnancy loss was referred to the Institute of Genetics for cytogenetic evaluation. Chromosomal analysis of the phenotypically normal parents was done to ascertain the role of chromosomal abnormalities and offer appropriate genetic counseling.