Publications by authors named "Cindy T K Lim"
Article Synopsis
- Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder that can lead to severe complications like blood clots, kidney failure, and increased mortality due to uncontrolled activity of the immune system.
- A study analyzed data from patients in the Korean National PNH Registry to evaluate how certain factors, especially lactate dehydrogenase (LDH) and hemoglobin levels, impact risks of complications and death in those not treated with complement inhibitors.
- Results showed that high LDH levels and male sex increased the risk of thrombosis, while low hemoglobin did not predict serious outcomes; thus, managing hemolysis in PNH patients could enhance their health results.
Background: In the single-arm CHRYSALIS trial, advanced non-small cell lung cancer patients harboring epidermal growth factor receptor () exon 20 insertion (Exon 20ins) showed durable responses to amivantamab, an EGFR-MET bispecific antibody targeting tumors with Exon 20ins. This study compared the effectiveness of amivantamab to real-world systemic anti-cancer therapies in Japan.
Patients And Methods: External control patients were selected by applying CHRYSALIS eligibility to Japanese patients from LC-SCRUM-Asia.
Background: Streptococcus agalactiae (group B Streptococcus [GBS]) has not been described as a foodborne pathogen. However, in 2015, a large outbreak of severe invasive sequence type (ST) 283 GBS infections in adults epidemiologically linked to the consumption of raw freshwater fish occurred in Singapore. We attempted to determine the scale of the outbreak, define the clinical spectrum of disease, and link the outbreak to contaminated fish.
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