Publications by authors named "Cindy Q Zhou"

Article Synopsis
  • Mutant EGFR is a key driver in non-small cell lung cancer (NSCLC), and while EGFR tyrosine kinase inhibitors (TKIs) like osimertinib are effective initially, most patients experience disease progression within 10-19 months due to drug-tolerant cells.
  • Research shows that while osimertinib partially inhibits EGFR activation, tumor cells can reactivate survival signaling pathways, leading to regrowth after about 35 days of treatment.
  • The combination of osimertinib with an antibody against hepatoma-derived growth factor (HDGF) resulted in better tumor responses and prolonged survival in mice, suggesting that targeting HDGF might improve NSCLC treatment outcomes.*
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The odontoma is regarded as a hamartomatous process of the jaws. Most are discovered as an incidental radiographic finding, averaging 15 mm in size. This report describes a case of a diminutive odontoma that was surgically removed before the onset of eruptive and pathologic consequences.

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Background: Neurofibromas are benign peripheral nerve sheath tumors usually featured with neurofibromatosis type 1 syndrome. Recurrent gingival neurofibromas have been rarely reported in the periodontal literature, particularly affecting elderly patients.

Methods And Results: A 70-year-old man with a pale, rubbery, and painless thickening along the facial/buccal gingiva of the mandibular right canine and first premolar.

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Objective: This article reports a case of a longstanding, slowly enlarging intraoral spindle cell lipoma (SCL) that had become increasingly painful during mastication.

Background: The SCL represents an uncommon variant of the conventional lipoma. There is limited information regarding this lesion in the gerodontologic literature.

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Osteopontin and MMP9 are implicated in angiogenesis and cancer progression. The objective of this study is to gain insight into the molecular mechanisms underlying angiogenesis, and to elucidate the role of osteopontin in this process. We report here that osteopontin/αvβ3 signaling pathway which involves ERK1/2 phosphorylation regulates the expression of VEGF.

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