Publications by authors named "Cindy Nennig"
Background: The ThinPrep® Imaging System (TIS) is a Food and Drug Administration-approved review system for cervical cytopathology, where it has been shown to increase performance over manually reviewed slides. Application of the TIS to urinary cytology has only been reported in a single study, in 2013.
Methods: We aimed to compare the agreement of two cytotechnologists' and a pathologist's manual screening (dots) with the fields of view (FOVs) selected by the TIS.
Article Synopsis
- Overexpression of p16 has been linked to high-grade urothelial cancers and can be detected through p16/Ki-67 dual labeling, which helps identify aggressive cases even when initial cytology results are inconclusive.
- The study analyzed 208 archived urinary samples, reclassifying them according to the 2015 Paris System for Reporting Urinary Cytology, to assess the effectiveness of p16/Ki-67 labeling in determining patient outcomes.
- Results showed that while the sensitivity of p16/Ki-67 was comparable to urinary cytology, its use indicated shorter disease-free survival for certain classifications, suggesting it may be valuable for managing patients with non-muscle-invasive urothelial carcinoma.