Publications by authors named "Cindy L Balasubramanian"
Nat Biotechnol
October 2014
Article Synopsis
- Many antibody-drug conjugates (ADCs) are unstable in the body due to their sensitive linkages that can easily break down.
- Researchers developed a new drug-linker using diaminopropionic acid (DPR) that has a basic amino group to stabilize the thiosuccinimide ring, which helps prevent loss of the drug.
- In animal studies, this new linker technology showed greater stability, resulting in better antitumor effects and fewer blood-related side effects.
