Publications by authors named "Cindy Ingraham"
Introduction: Genome-wide association studies have identified over 70 genetic loci associated with late-onset Alzheimer's disease (LOAD), but few candidate polymorphisms have been functionally assessed for disease relevance and mechanism of action.
Methods: Candidate genetic risk variants were informatically prioritized and individually engineered into a LOAD-sensitized mouse model that carries the AD risk variants APOE ε4/ε4 and Trem2*R47H. The potential disease relevance of each model was assessed by comparing brain transcriptomes measured with the Nanostring Mouse AD Panel at 4 and 12 months of age with human study cohorts.
Article Synopsis
- Genome-wide studies have found over 70 genetic loci linked to late-onset Alzheimer's disease, but few have been thoroughly tested for their role in the disease.
- Researchers used a LOAD-sensitive mouse model to evaluate 11 potential genetic variants, analyzing their effects on brain gene expression at different ages.
- The findings reveal similarities between the genetic models and human Alzheimer's gene patterns, suggesting these models could be useful for developing targeted treatments.