Publications by authors named "Cindy Alejandra Gutierrez-Valenzuela"
Article Synopsis
- This study investigates how different formulation parameters impact the creation of poly-dl-lactic-glycolic nanoparticles using emulsification-solvent evaporation and nanoprecipitation techniques.
- The research focuses on varying factors such as polymer and tensoactive concentrations, organic solvent fractions, and sonication or injection speeds to influence the nanoparticles' characteristics.
- Through methods like dynamic light scattering and scanning electron microscopy, the study demonstrates that adjusting these parameters can lead to nanoparticles of specific sizes and stability, enabling consistent results in their preparation.
Background/aim: Cancer incidence and mortalities are growing worldwide, therefore research and development of more effective and less invasive treatments, such as photodynamic therapy, are needed. Herein, we investigated the methylene blue (MB) photoactivation effects in lung epithelial cells (BEAS-2B) and lung adenocarcinoma cells (H-441).
Materials And Methods: The reactive oxygen species (ROS) produced by the laser photoactivation of MB in aqueous solutions and cell cultures were measured with probes, and the cell viability was evaluated with a colorimetric assay.
In this study we describe a mathematical analysis that considers the temperature effects of the controlled drug release process from biodegradable poly-d,l-lactide--glycolide (PLGA) nanoparticles. Temperature effects are incorporated and applied to two drug release models. The first one consists of a two-stage release process that considers only simultaneous contributions of initial burst and nanoparticle degradation-relaxation (BR model).
View Article and Find Full Text PDF