Publications by authors named "Cindi Emerson"
Article Synopsis
- Tenofovir alafenamide yields higher concentrations of tenofovir diphosphate (tenofovir-dp) in PBMCs compared to tenofovir disoproxil fumarate, which is significant for its use in pre-exposure prophylaxis.
- Healthy women were given varying doses of tenofovir alafenamide, and samples were analyzed to assess drug concentration and tissue distribution.
- Despite effective conversion of the drug to tenofovir-dp in certain epithelial cells, the study found that tenofovir-dp was largely unquantifiable in most mucosal tissues following dosing, indicating potential limitations in tissue effectiveness for protection.
Models for predicting effective HIV chemoprevention in women.
J Acquir Immune Defic Syndr
April 2015
Objective: Model systems that rapidly identify tissue drug concentrations protective of HIV infection could streamline the development of chemoprevention strategies. Tissue models are promising, but limited concentration targets exist, and no systematic comparison to cell models or clinical studies has been performed.
Design: We explored the efficacy of maraviroc (MVC) and tenofovir (TFV) for HIV prevention by comparing Emax models from TZM-bl cells to vaginal tissue explants and evaluated their predictive capabilities with a dose-challenge clinical study.
: A comparative analysis of cellular and soluble markers of immune activation in HIV-infected women on combination antiretroviral therapy showed that the upper genital tract (UGT) compared to the lower female genital tract was characterized by higher frequencies of potential HIV target cells and increased inflammatory molecules. Despite the activated UGT milieu, HIV RNA could not be detected in paired samples of plasma, cervicovaginal or endometrial lavage. As antiretroviral concentrations were ≥3-fold higher in the endometrium than in the lower genital tract, high antiretroviral penetration and/or metabolism may limit viral replication in the UGT.
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