Clinical and Functional Outcomes of Kinematic Aligned Total Knee Arthroplasty with a Medial Pivot Design: Two-Year Follow-Up.

Background: Kinematic alignment (KA) restores native limb alignment following total knee arthroplasty (TKA). The association of this technique with a medial pivot implant design attempts to re-establish the physiological kinematics of the knee. This study aims to analyze the clinical and radiological outcomes of patients undergoing MP-TKA with kinematic alignment and to assess the effect of limb alignment on the clinical outcomes.

Analysis of Short-Term Clinical and Functional Outcomes in Patients Undergoing Total Knee Arthroplasty with Kinematic Alignment Technique.

Background: Surgery remains the best option for more advanced stages of knee osteoarthritis (OA). Kinematic alignment (KA) is an innovative surgical technique that aims to co-align the rotational axes of the femoral, tibial, and patella components with the three kinematic axes of the knee. This study aims to evaluate and analyze short-term clinical, psychological, and functional outcomes in patients undergoing total knee replacement with the KA technique.

Comparison of early functional outcomes between two different surgical approaches for total hip arthroplasty.

Total Hip Arthroplasty (THA) is considered the most successful treatment for advanced hip osteoarthritis. Different surgical approaches for THA are available and they have shown excellent outcomes in the long-term follow-ups. However, few studies have analyzed the functional outcomes in the first days after a THA surgery.

[Functional mitral insufficiency].

The term "functional mitral regurgitation" is generally used to indicate the presence of mitral regurgitation in patients with left ventricular systolic dysfunction in the absence of structural abnormalities of mitral leaflets and chordal or papillary muscle rupture. Functional mitral regurgitation is commonly found in heart failure, and its presence and severity seem to contribute to exercise intolerance and poor prognosis observed in heart failure patients. Several pathogenetic mechanisms have been proposed to explain the pathophysiology of functional mitral regurgitation, in particular a) mitral annular dilation, b) geometric changes in the left ventricle from a typical ellipsoidal shape to a more spherical shape, with apical and outward displacement of papillary muscles and restriction of valve motion ("leaflet tethering hypothesis"), and c) reduction of closing force of the mitral valve ("leaflet closing force hypothesis"), as a consequence of a lower difference between left ventricular systolic pressure (reduced from left ventricular dysfunction) and left atrial pressure (increased).

Paroxysmal electroencephalographic abnormalities genetically transmitted: one family description.

A 10-year-old girl came to our observation since a general rule-out electroencephalogram (EEG) had showed, in absence of any clinical manifestation, generalized and symmetrical 3 c/s spike-and-wave bursts, whose duration was longer than 3 s. The subject, only daughter born from her mother's first marriage, had no family history of neurological diseases; her physical and neuropsychological examinations were normal. A polysomnographic recording showed, during sleep, the same abnormalities observed during wakefulness.

[Multicenter trials of a new cephalosporin (ceftriaxone) in childhood].

AA. have tested a new drug (Ceftriaxone) on 40 children affected by upper and lower respiratory tract infectious diseases. As shown by results, this new drug has been remarkably effective and easy to use since it may be administered once in a day; moreover, the tested drug has not caused any kind of tissue or parenchymal involvement.

[A case of Jaffé-Lichtenstein fibrous dysplasia. Etiopathogenetic findings].

The AA. report a case of Jaffé-Lichthenstein Fibrous Dysplasy, a relatively rare syndrome whose aetiopathogenesis is still discussed. Blood laboratory data of the patient and of his family suggest a genetic background on the upon mentioned syndrome.

[The effects of verapamil on angina threshold during exercise (author's transl)].

The efficacy and duration of the effects of verapamil on angina threshold during exercise were examined in five patients with proved angina pectoris, with the experimental model of a latin square 5 X 5. The effects of verapamil (0,1 mg/kg i.v.