Publications by authors named "Cilene Reboucas Lima"
Article Synopsis
- - The study explores how high glucose levels affect human periodontal ligament (PL) cells, focusing on their shape, movement, and ability to stick to surfaces due to changes in specific microRNAs (miR-221 and miR-222).
- - Results indicate that high glucose reduces PL cell adhesion and migration, leading to unstable cell structures and impaired healing processes, particularly relevant for patients with unmanaged diabetes.
- - The findings suggest that the negative impacts of high glucose on PL cells may be linked to the downregulation of miR-221 and miR-222, which could hinder effective healing in periodontal treatments.
Article Synopsis
- The study assessed two radioimmunoconjugates, In-DTPA-trastuzumab and Lu-DOTA-trastuzumab, focusing on how different chelating agents affect their properties and binding to HER2 tumor cells.
- Despite the variations in chelating agents, the molar ratios (1:10 and 1:20) did not compromise the integrity, labeling process, or stability of the antibodies.
- However, notable differences were found in the lipophilicity and binding efficiency to HER2 positive SK-BR-3 cells, indicating that selecting the right chelating agent and ratio is crucial for developing effective radioimmunoconjugates.
Vitreous alterations occur from early stages and continue through the normal aging, with gradual lamellae formation and the appearance of liquefied spaces, which eventually leads to complications, such as retinal tear, retinal detachment, and intravitreal hemorrhage. The aim of the present study was to investigate the expression of let-7 miRNA family in the vitreous and retina in newborn (1-3- day-old), young adult (2-month-old), and aging (12-month-old) rats, as well as their role as regulators of vitreous components. MicroRNAs are small, non-coding RNAs that post-transcriptionally regulate gene expression.
View Article and Find Full Text PDFThe deregulation of transcription and processing of microRNAs (miRNAs), as well as their function, has been involved in the pathogenesis of several human diseases, including cancer. Despite advances in therapeutic approaches, cancer still represents one of the major health problems worldwide. Cancer metastasis is an aggravating factor in tumor progression, related to increased treatment complexity and a worse prognosis.
View Article and Find Full Text PDFBackground: Tumor invasiveness is directly related to the ability of tumor cells to migrate and invade surrounding tissues, usually degrading extracellular matrix. Despite significant progress in the knowledge about migration and invasion, there is much more to elucidate about their regulatory mechanisms, especially in cancer cells. MicroRNAs (miRs) were recently described as important regulators of migration.
View Article and Find Full Text PDFBackground: Fibroadenoma is the most common breast tumor in young women, and its growth and metabolism may be under hormonal control. In the present paper we described the proteoglycan (PG) composition and synthesis rate of normal breast and fibroadenoma during the menstrual cycle.
Methods: Samples of fibroadenoma and adjacent normal breast tissue were obtained at surgery.