Synthesis of novel coumarin-triazole hybrids and first evaluation of the 4-phenyl substituted hybrid loaded PLGA nanoparticles delivery system to the anticancer activity.

Despite the discovery of many chemotherapeutic drugs that prevent uncontrolled cell division processes in the last century, many studies are still being carried out to develop drugs with higher anticancer efficacy and lower level of side effects. Herein, we designed, synthesized, and characterized six novel coumarin-triazole hybrids, and evaluated for anticancer activity of the one with the highest potential against the breast cancer cell line, MCF-7 and human cervical cancer cell line, human cervical adenocarcinoma (HeLa). Compoundwhich was the coumarin derivative including phenyl substituent with the lowest IC50 value displayed the highest cytotoxicity against the studied cancer cell line.

Trace nickel determination in seawater matrix using combination of dispersive liquid-liquid microextraction and triethylamine-assisted Mg(OH) method.

In order to eliminate the effects of seawater matrix on the precise/accurate determination of elements, new and efficient analytical procedure requires. In this study, co-precipitation method based on the triethylamine (TEA)-assisted Mg(OH) was performed to eliminate side-effects of seawater medium on the determination with flame atomic absorption spectrometry (FAAS) prior to the preconcentration of nickel by an optimized dispersive liquid-liquid microextraction (DLLME) method. Under the optimum conditions of the presented method, the limit of detection and quantification (LOD, LOQ) values obtained for nickel were found as 16.

Determination of trace cobalt ions in bottled drinking water samples from Fiji Island by spray-assisted fine droplet formation-liquid phase microextraction based on simultaneous complexation and extraction before flame atomic absorption spectrometer measurement.

In this study, a green, simple and effective preconcentration method named as spray-assisted fine droplet formation-liquid phase microextraction (SAFDF-LPME) before the flame atomic absorption spectrophotometry (FAAS) measurement for cobalt determination was developed. The method reduces the external dispersive solvent usage by using a simple spraying apparatus to obtain fine droplets of the extraction solvent. SAFDF-LPME method also consists of simultaneous complexation and extraction which indicates the environmental benevolence of the developed method.

Synthesis of New Di- and Triamides as Potential Organocatalysts for Asymmetric Aldol Reaction in Water.

New di- or triamide organocatalysts derived from (L)-proline were synthesized and successfully used in the direct asymmetric aldol reaction of aliphatic ketones and aromatic aldehydes in water at 0oC in the presence of benzoic acid as co-catalyst. (S)-methyl-2-((S)-3-hydroxy-2-((S)-3-pyrrolidine-2-carboxamido)propanamido)-3-phenylpropanoate (7c) as organocatalyst showed best results under these reaction conditions, and good diastereoselectivities (up to 99%), enantioselectivities (up to 98%) and yields (up to 91%) were observed.

New nanodrug design for cancer therapy: Its synthesis, formulation, in vitro and in silico evaluations.

The aim of this study was to develop a novel nanosize drug candidate for cancer therapy. For this purpose, (S)-methyl 2-[(7-hydroxy-2-oxo-4-phenyl-2H-chromen-8-yl)methyleneamino]-3-(1H-indol-3-yl)propanoate (ND3) was synthesized by the condensation reaction of 8-formyl-7-hydroxy-4-phenylcoumarin with l-tryptophan methyl ester. Its controlled release formulation was prepared and characterized by different spectroscopic and imaging methods.

Epibatidine alkaloid chemistry: 5. Domino-Heck reactions of azabicyclic and tricyclic systems.

Palladium-catalyzed hydroarylations and additional domino reactions of aza-bicyclic and tricyclic norbornene derivatives were investigated and a series of new epibatidine analogues were synthesized.

Synthesis of new pyrazolothiazole derivatives from 4-thiazolidinones.

The synthesis of new 2,3,5,6-aryl substituted tetrahydro-2H-pyrazolo[3,4-d]- thiazoles 4a-j as potential biologically active compounds by the cyclocondensation of phenyl hydrazine with new 5-arylidene derivatives 2a-j of 2,3-disubstituted-1,3- thiazolidin-4-ones 1a-e is reported.