Publications by authors named "Cidan Yang Ji"
Differences in proteomic profiles between yak and three cattle strains provide insights into molecular mechanisms underlying high-altitude adaptation.
Jin-Wei Xin Zhi-Xin Chai Cheng-Fu Zhang Qiang Zhang Yong Zhu Cidan YangJi Hui Jiang Jin-Cheng Zhong Qiu-Mei Ji
J Anim Physiol Anim Nutr (Berl)
May 2022
Article Synopsis
- Yaks have unique lung and heart adaptations for high-altitude living, but the specific molecular mechanisms are not well understood.
- A study compared the proteins in the lung and heart tissues of yaks to three cattle strains using advanced proteomic techniques, identifying over 7,200 proteins and numerous proteins that are differentially abundant.
- The analysis revealed specific protein pathways related to immune function and cardiac performance that may explain how yaks manage low oxygen levels and maintain heart function in high altitudes.
Article Synopsis
- - The study investigates how yaks have adapted to high-altitude living by focusing on long non-coding RNAs (lncRNAs) in their gluteus muscle compared to different cattle breeds.
- - Researchers found that yaks have higher expressions of genes related to fatty acid oxidation and lower expressions of glucose metabolism genes, suggesting a shift in energy use to adapt to their environment.
- - The findings also indicate unique lncRNA functions that may help yaks manage stress and muscle function, with results showing differences in calcium handling and muscle contraction mechanisms when compared to cattle species.
Signature of high altitude adaptation in the gluteus proteome of the yak.
Jin-Wei Xin Zhi-Xin Chai Cheng-Fu Zhang Qiang Zhang Yong Zhu Cidan Yang Ji Hui Jiang Jin-Cheng Zhong Qiu-Mei Ji
J Exp Zool B Mol Dev Evol
September 2020
Article Synopsis
- Yak exhibits unique adaptations to the high-altitude Qinghai-Tibetan Plateau, and a study analyzed the proteomic profiles of yak gluteus muscle compared to various cattle strains to understand these mechanisms.
- The research identified significant differences in protein expression: yak had 20, 364, and 143 upregulated proteins compared to Tibetan, Holstein, and Sanjiang cattle, respectively, with many related to energy processes like oxidative phosphorylation.
- Key proteins associated with increased mitochondrial capacity and protection against oxidative damage were found in yaks, indicating their enhanced metabolic function is a long-term adaptation to survive in high-altitude environments.