Sexual Function Under Adequate Estrogen Therapy in Women After Oophorectomy Versus Natural Menopause.

There is scarce evidence regarding endogenous postmenopausal ovarian testosterone (T) production and estrogen replacement roles in different sexual domains. This study aimed to determine whether lower endogenous T in oophorectomized women that were estradiol (E2)-treated influenced global or specific domains of sexual function. Depressive and cognitive symptoms were evaluated to exclude potential confounders.

Low testosterone levels are associated with endothelial dysfunction in oophorectomized early postmenopausal women.

Background: The actual consequences of low testosterone levels in women remain uncertain.

Objective: To assess endogenous testosterone influence on body composition, vascular and metabolic function in recent postmenopausal women.

Design: We studied 81 postmenopausal women under transdermal estradiol (E2) replacement therapy, 36 with bilateral oophorectomy (group O), and 45 controls (group C) through venous occlusion plethysmography, bioimpedance, DEXA, biochemical, hormonal, and inflammatory profile.