Publications by authors named "Ciaran Gunn"
Neurogranin (Ng), a post-synaptic protein involved in memory formation, has been investigated as a biomarker in the cerebrospinal fluid (CSF) in Alzheimer's disease (AD) and ageing. CSF Ng levels are elevated in AD relative to healthy controls and correlate with cognition; however, few studies have focused on Ng abundance in the brain. Synapse loss in the brain correlates closely with cognitive decline in AD making synaptic biomarkers potentially important for tracking disease progression, but the links between synaptic protein changes in CSF and brain remain incompletely understood.
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- The study looks at why older people might get Alzheimer's or have trouble thinking as they age.
- Researchers examined brains from different age groups and conditions to see how synapses (the connections between brain cells) change.
- They found that healthy brains had better synaptic health and fewer problems compared to those with cognitive decline or Alzheimer's, which suggests that strong brain connections help with thinking as we get older.