Camphanic acid chloride: a powerful derivatization reagent for stereoisomeric separation and its DMPK applications.

Background: Camphanic acid chloride has proven to be an efficient chiral derivatization reagent for determination of stereoisomers.

Results: The utility of chemical derivatization of various stereoisomers containing hydroxy functional groups with camphanic acid chloride in the presence or absence of a base is highlighted. This procedure is shown to be relatively simple, fast and a cost-effective method of separating racemic drugs and stereoisomeric metabolites in biological matrices.