A multivariate exploration of basic symptoms.

Little is known about the relationship between the different categories of basic symptoms (BS). Researchers of the Bonn School have accurately described the progression from second-level BS (relatively characteristic BS) to first-rank Schneiderian symptoms. Using a multiple regression model, the present study tried to investigate which kind of dynamic deficiencies (DDs; uncharacteristic first-level BS) mostly lead to each type of second-level BS.

Patterns of adaptation in asthma and psoriasis.

Patterns of adaptation to a conflict situation were explored by means of the repeated confrontation with the Stroop task (Serial Color-Word Test) in two clinical groups: bronchial asthma (n=40) and psoriasis (n=28). The respective psychosomatic component of each of these syndromes was expected to correspond to peculiar patterns of adaptation. Differences between asthma and psoriasis patients were statistically significant.

Patterns of adaptation and directions of aggression.

A group of 85 nonclinical women volunteers were given the Serial Color-Word Test and the Personality Deviance Scale to verify whether different patterns of adaptation to the Stroop task correspond to significant differences in directing aggression. It was predicted that subjects with the Dissociative pattern, i.e.

Patterns of adaptation and school performance: a pilot study.

A group of 34 pupils from two school classes (Class 8, M = 13.1 yr., SD=0.

Self-report of basic symptoms among psychotic and nonpsychotic subjects.

Basic symptoms, as defined and described by the Bonn Scale, were assessed by means of a new self-report inventory, the Rome Basic Disorders Scale. On all the subscales, psychiatric outpatients (n = 105; most frequent diagnoses: Schizophrenia, Anxiety Disorders, and Mood Disorders) scored significantly higher (p < .001) than nonclinical controls (n = 105).

Perceptual defense mechanisms in Crohn's disease and panic disorder.

The defense organization of Crohn's disease and Panic Disorder was studied with a well-validated tachistoscopic paradigm, the Defense Mechanism Test. Three sex- and age-matched groups of 34 subjects (Crohn, Panic, and Nonclinical) were compared on the main codings of defense. Crohn patients were characterized by stereotypy and lack of recognition of the threat.

Perceptual defenses and self-rated personality disorders: a multivariate analysis.

The relationships between defense mechanisms and personality disorders were explored by means of the Defense Mechanism Test and Millon's Inventory-II in a group of 100 psychiatric nonpsychotic outpatients. Only few significant positive nonparametric correlations were found, concerning barrier isolation, intro-aggression, and lateness of the threat. Also multiple regression analysis evidenced few significant results and mostly in the negative direction.

General cognitive abilities and patterns of adaptation: for Serial Color-Word Test norms based on reading times.

In a pool of 859 clinical and nonclinical Serial Color-Word Test protocols, significant positive correlations were observed between reading times on the Stroop task and measures of linear and nonlinear change. Especially nonlinear change, both within and between the five subtests, showed high correlations with reading times. To derive new time-related norms, the sample was divided into five time groups of the same size and stratified medians were calculated for each of the variables of the test.

Foulds' hierarchy: validation of predictions in psychiatric and dermatological patients.

Foulds' inclusive non-reflexive law of symptom formation has been hitherto confirmed only on psychiatric or non-clinical persons. Given that respectively a yes-bias and a high frequency of non-classified patients may have inflated the rate of confirming protocols in these groups, a validation study was conducted with the Delusions-Symptoms-States Inventory (DSSI) on 188 psychiatric and 295 dermatological patients. Although non-classified patients were not included in the study (thus lowering the number of conforming patterns), both samples showed percentages of patterns conforming to Foulds' law which were above 85 per cent.

Styles of regulation in the bipolar spectrum.

Styles of regulation were assessed with the Serial Color-Word Test in a group of 35 compensated DSM-III--R bipolar patients (Bipolar) and in 3 control groups: Major Depression (n = 35), Schizophrenia (n = 50), and self-rated Personality Disorder (n = 40). On several measures of nonlinear change (V), patients in the Bipolar group had mean scores between those of the Personality Disorder and the Schizophrenic groups, and overlapped with those of the Major Depression group. Patients in the Bipolar group with clearcut temperaments (hyperthymic or depressive) were significantly more dissociative and less stabilized than other patients in the same group.

Personality disorders and psychiatric symptoms in psoriasis.

Two groups of psoriatic outpatients (ns = 192 and 119) were given, respectively, the Million Clinical Multiaxial Inventory-II and Foulds' Delusions-Symptoms-States Inventory. They were compared with dental (n = 192) and with general surgical (n = 190) patients. The psoriatic group presented clearly higher mean scores and frequencies on most of the personality disorder scales.

Effects of fluoxetine on aggressive behavior of adult inpatients with mental retardation and epilepsy.

Nineteen mentally retarded inpatients with epilepsy and a history of current or recent aggressive behavior were treated with 20 mg of fluoxetine daily. All were concurrently taking other psychotropic medications, including carbamazepine and neuroleptics. A standardized rating scale (MOAS) was used to assess the effects of fluoxetine on aggressive behavior.

Melancholia: a Defense Mechanism Test study.

The defensive organization of Melancholia was explored with a tachistoscopic percept-genetic technique, the Defense Mechanism Test. A sample of 20 women inpatients with a DSM-III-R diagnosis of Major Depressive Episode or Major Depression, Melancholic Type was contrasted with a matched group of depressed outpatients and a matched group of nonclinical subjects. Signs of introaggression on the hero, statue-repression, and stereotypy significantly characterized melancholic patients.

The efficacy and safety of tianeptine in the treatment of depressive disorder: results of a controlled double-blind multicentre study vs. amitriptyline.

Three hundred in- and outpatients suffering from depressive disorder, as diagnosed using DSM-III criteria were treated for 6 weeks under double-blind conditions in a multicenter controlled study of tianeptine vs. amitriptyline. Both groups presented steady improvement of depressive syndrome from day 7 up to the end of the treatment, as shown by all evaluation scales: HDRS, SAD, CGI.

Assessment of depression in Alzheimer's disease: symptoms, syndrome, and computed tomography findings.

The Hamilton Rating Scale for Depression (HAM-D) and DSM-III-R criteria were simultaneously employed to assess the prevalence of depression in 26 outpatients with dementia of the Alzheimer type and 26 age-matched normal control subjects. Both assessment methods evidenced a higher frequency of depression during the severe stages of Alzheimer's disease. Among the Alzheimer patients, the prevalence rate of depression produced by the HAM-D (38%) was higher than the rate produced by DSM-III-R criteria (23%).

Mania, loss and defense: a percept-genetic investigation.

The defensive organization of manic states has been investigated with the Defense Mechanism Test-Separation Theme. A black and white stimulus portraying a mother figure who is leaving an infant alone was presented tachistoscopically, at increasing durations of exposure, to 22 inpatients who had had a manic episode and to 22 age- and sex-matched normal controls. The manic group was characterized by the following six major defense codings: (1) the infant is able to walk or run, (2) the mother is a rigid, inanimate being, (3) the mother is veiled or disguised, (4) the mother is protective or inviting, (5) the mother is seen as a male figure, and (6) colors are perceived in the colorless stimulus.

Alexithymia as related to sex, age, and educational level: results of the Toronto Alexithymia Scale in 417 normal subjects.

The Toronto Alexithymia Scale (TAS) was administered to 417 normal subjects. Total TAS scores and scores of the four TAS factors were correlated with sex, age, and educational level. Age ranged from 21 to 64 years.

A study of schizophrenic outpatients with the Defense Mechanism Test.

Intrapsychic defensive strategies are allegedly expressed on the Defense Mechanism Test through the presentation, at increasing tachistoscopic exposure times, of a picture in which a central figure is threatened by a peripheral person. Several types of perceptual alterations of the stimulus configuration are coded as defenses in the subjective reports. A number of test variables have already been shown to differentiate significantly between nonclinical controls and nonpsychotic psychiatric patients.

Negative symptoms and visual behavior in DSM-III-R prognostic subtypes of schizophreniform disorder.

Eighteen male patients with a DSM-III-R diagnosis of schizophreniform disorder were rated on the Scale for the Assessment of Negative Symptoms and their visual behavior during interview was recorded through an ethological technique. Affective flattening, alogia and the global severity of the negative-symptom syndrome were found to be more prominent among poor-prognosis patients. In addition, compared with patients with good prognostic features, poor-prognosis patients showed a pattern of visual behavior (less eye contact and more eye closures) suggesting poor rapport with the interviewer.

5-HT2 receptor antagonism in dysthymic disorder: a double-blind placebo-controlled study with ritanserin.

Thirty patients suffering from dysthymic disorder participated in a 6-week double-blind trial comparing ritanserin 10 mg and placebo. After a single-blind placebo wash-out period of one week, the test medication was administered during 5 weeks on a double-blind basis. Twenty-three patients completed the study.

5-HT2 antagonist ritanserin in neuroleptic-induced parkinsonism: a double-blind comparison with orphenadrine and placebo.

Several studies support the hypothesis of 5-HT (serotonin) involvement in the physiopathology of the extrapyramidal system. Ritanserin is a new compound with a high, selective, and long-lasting binding affinity for 5-HT2 receptors. A therapeutic effect of ritanserin has been reported in Parkinson's tremor and L-Dopa-induced dyskinesias but no effect was seen in essential tremor.

Ethological assessment of the DSM-III subtyping of unipolar depression.

An ethological method was employed to validate the DSM-III subtyping of unipolar, nondelusional depression. The nonverbal behavior of 44 depressed outpatients was video-recorded during psychiatric interview. The DSM-III subtyping was not significantly associated with sex or level of education.

Ethological predictors of amitriptyline response in depressed outpatients.

Non-verbal behaviour of 22 unipolar, non-delusional depressed outpatients was video-recorded during psychiatric interview to determine whether response to tricyclic treatment (50-100 mg/day of amitriptyline for 5 consecutive weeks) could be predicted on the basis of the ethological profile at baseline. At the end of the study, patients were divided into two treatment outcome groups on the basis of their final Hamilton Depression Rating Scale (HDRS) scores. At baseline, responders (n = 14, HDRS score less than or equal to 10) and non-responders (n = 8, HDRS score greater than 10) did not differ with respect to sex, age, education, DSM-III diagnosis, and HDRS score.

Separation-individuation, aggression and alexithymia in psoriasis.

A psychosomatic study of psoriasis was conducted in order to: 1) assess the level of extra- and intra-aggression (cf. the conflicting results in Matussek et al. (1) and Lyketsos et al.