Bisphosphonate-related osteonecrosis of the jaw: Current clinical significance and treatment strategy review.

Purpose: This review paper is intended to provide updated information about the significance of bisphosphonate-related osteonecrosis of the jaw (BRONJ) related to dental departments and also to provide treatment information. However, it does not review anti-resorptive related osteonecrosis of the jaw (ARONJ).

Methods: PubMED was searched for published articles on BRONJ that have particular relevance to clinical aspects in orthodontics, endodontics, periodontics, prosthodontics, oral and maxillofacial surgery, implants and treatment planning.

Phosphate buffer-stabilized 0.1% chlorine dioxide oral rinse for managing medication-related osteonecrosis of the jaw.

Purpose: This is a review of the literature on nonsurgical treatment of non-healing medication related osteonecrosis of the jaw (MRONJ) utilizing a phosphate buffer-stabilized 0.1% chlorine dioxide mouthrinse.

Methods: A literature search in PubMed revealed only six case reports.

Comparison of 3 intranasal mists for anesthetizing maxillary teeth in adults: A randomized, double-masked, multicenter phase 3 clinical trial.

Background: This double-masked, parallel-design, clinical trial assessed whether a combination nasal spray (K305; 3% tetracaine hydrochloride and 0.05% oxymetazoline hydrochloride) compared with a tetracaine-only spray and a placebo spray would be safer and superior in producing local anesthesia sufficient to complete a direct restorative procedure in maxillary nonmolar teeth.

Methods: The authors randomized eligible patients to receive K305 spray (n = 44), tetracaine hydrochloride spray (n = 44), or a placebo solution (n = 22).

Mouthwashes: Rationale for use.

Purpose: To update the rationale for the use of mouthwashes and summarize data on the incorporation of an antibacterial, cetylpyridinium chloride (CPC), into a new mouthwash formulation. Data from various published articles are reviewed which demonstrate the value of mouthwashes. Also this Special Issue provides research supporting the efficacy of 0.

Can Chemical Mouthwash Agents Achieve Plaque/Gingivitis Control?

Also note that structured abstracts are not allowed per journal style: What is the effect of a mouthwash containing various active chemical ingredients on plaque control and managing gingivitis in adults based on evidence gathered from existing systematic reviews? The summarized evidence suggests that mouthwashes containing chlorhexidine(CHX) and essential oils (EO) had a large effect supported by a strong body of evidence. Also there was strong evidence for a moderate effect of cetylpyridinium chloride(CPC). Evidence suggests that a CHX mouthwash is the first choice, the most reliable alternative is EO.

Management of Gingival Overgrowth in a Cardiac Transplant Patient Using Laser-Assisted Gingivectomy/Gingivoplasty.

Drug-induced gingival overgrowth (DIGO) is an oral clinical manifestation associated with certain medications such as immunosuppressants that are administered to organ transplant patients to prevent graft rejection. In patients with cardiac transplants, management of DIGO is critical. In such patients, plaque biofilm accumulation at the gingival interface might be detrimental as it may lead to transient bacteremia as well as systemic inflammation resulting in thromboembolic events.

Evaluation of adjunctive systemic doxycycline with non-surgical periodontal therapy within type 2 diabetic patients.

Objectives: To evaluate the effects of systemic doxycycline on clinical and microbiological parameters of diabetic subjects with chronic periodontitis.

Methods: This 9-month multi-center, randomized, parallel, single-blinded study was conducted from different hospitals in Riyadh, Saudi Arabia between April 2010 and December 2010. A total of 76 diabetic subjects with chronic periodontitis were randomized into 2 groups: control group (CG) received only scaling and root planing (SRP), and the treatment group (TG) receiving systemic doxycycline during the reevaluation visit 45 days after the completion of SRP.

A pilot test of motivational oral health promotion with alcohol-dependent inpatients.

Objective: Motivational interviewing (MI) is an effective intervention for improving health behavior in a number of domains, and evidence suggests that it may be useful for promoting oral health. The current pilot study was designed to provide initial evidence that, compared with a didactic control intervention, a brief MI-based intervention (BMI) delivered by dental practitioners can yield greater improvements in oral hygiene, health-care utilization, and health outcomes in a population at heightened risk for oral disease.

Method: Either the control intervention or BMI, delivered by a dentist or a dental hygienist, was randomly assigned to 60 individuals in inpatient treatment for alcohol-use disorders.

The prevalence of oral Candida infections in periodontitis patients with type 2 diabetes mellitus.

Objectives: The purpose of this study was to determine the prevalence of Candida spp. in periodontitis patients with type 2 diabetes mellitus.

Methods: This cross-sectional study included 42 diabetic patients with periodontitis (aged 21-70 years; 18 males and 24 females).

Safety and efficacy of a novel nasal spray for maxillary dental anesthesia.

This study examines the efficacy, safety, and tolerability of a nasal spray to induce anesthesia of maxillary teeth. Forty-five healthy adults requiring restoration of one maxillary tooth were randomized in a 1:2 ratio to receive (1) an intra-oral lidocaine-epinephrine injection with buffered saline nasal spray bilaterally, or (2) a tetracaine hydrochloride-oxymetazoline hydrochloride nasal spray bilaterally with sham injection. Primary endpoints were use of rescue anesthesia and patient global pain assessment.

An evaluation of 10 percent and 20 percent benzocaine gels in patients with acute toothaches: efficacy, tolerability and compliance with label dose administration directions.

Background: The authors evaluated the efficacy and tolerability of 10 percent and 20 percent benzocaine gels compared with those of a vehicle (placebo) gel for the temporary relief of toothache pain. They also assessed the compliance with the label dose administration directions on the part of participants with toothache pain.

Methods: Under double-masked conditions, 576 participants self-applied study gel to an open tooth cavity and surrounding oral tissues.

A novel formulation effective in killing oral biofilm bacteria.

Objective: To determine if a novel formulation is effective in killing oral biofilm streptococci in vitro and in vivo.

Methods: Efficacy of 0.5% levulinic acid and 0.

The effect of an 810-nm diode laser on postoperative pain and tissue response after modified Widman flap surgery: a pilot study in humans.

Background: The purpose of this single-masked pilot clinical study is to compare the tissue response and postoperative pain after the use of a diode laser (810 nm) (DL) as an adjunct to modified Widman flap (MWF) surgery to that of MWF alone.

Methods: Thirteen patients with generalized severe chronic periodontitis completed the study. Control sites were randomly selected to receive an MWF and the contralateral test sites an MWF in conjunction with a DL.

Diode laser activated indocyanine green selectively kills bacteria.

Background And Objective: Commercially available photodynamic therapy for periodontal diseases utilizes methylene blue as a photosensitizer. Here we propose a novel photosensitizer dye, indocyanine green (ICG), because it can be readily activated by commercially available dental 810 nm diode lasers and has an established safety record as an intravascular agent in cardiac imaging and ophthalmologic photodynamic therapy. Therefore, we aim to characterize ICG uptake and killing of key periodontal pathogens to explore its potential as a periodontal photodynamic therapy agent.

Metabolomics reveals elevated macromolecular degradation in periodontal disease.

Periodontitis is a chronic inflammatory disease characterized by tissue destruction. In the diseased oral environment, saliva has primarily been considered to act as a protectant by lubricating the tissue, mineralizing the bones, neutralizing the pH, and combating microbes. To understand the metabolic role that saliva plays in the diseased state, we performed untargeted metabolomic profiling of saliva from healthy and periodontitic individuals.