Publications by authors named "Cian Maguire"
Article Synopsis
- Transdermal drug delivery, through microarray patches (MAPs) with tiny needles, offers a solution to issues faced with orally and parenterally administered poorly soluble drugs.
- MAPs have mostly targeted hydrophilic drugs, but this study explores their potential for delivering the hydrophobic drug olanzapine using solubility-enhancing methods like cyclodextrin complexation and particle size reduction.
- Successful experiments demonstrated that olanzapine can be effectively delivered via MAPs, showing absorption rates comparable to oral administration, thus expanding the types of drugs that can be delivered transdermally.