Computer modelling and vegetable bench test of a bipolar electrode array intended for use in high frequency irreversible electroporation treatment of skin cancer.

Purpose: Pulsed electrical field (PEF) ablation is an energy-based technique used to treat a range of cancers by irreversible electroporation (IRE). Our objective was to use computational and plant-based models to characterize the electric field distribution and ablation zones induced with a commercial 8-needle array-based applicator intended for treatment of skin cancer when high-frequency IRE (H-FIRE) pulses are applied. Electric field characterisation of this device was not previously assessed.