Publications by authors named "Cian Gavin"
Article Synopsis
- Neuroblastoma is the most common solid tumor in children, yet those with recurrent or drug-resistant cases face dire survival rates below 20%.
- Researchers developed a cisplatin-resistant neuroblastoma model to study tumor behaviors, finding that resistant cells showed more metastases, particularly in lymph nodes.
- The study highlighted TNFRSF4 as a key gene with low expression linked to worse outcomes in neuroblastoma, making it a potential independent prognostic factor for survival.
Neuroblastoma is a paediatric malignancy of the developing sympathetic nervous system. About half of the patients have metastatic disease at the time of diagnosis and a survival rate of less than 50%. Our understanding of the cellular processes promoting neuroblastoma metastases will be facilitated by the development of appropriate experimental models.
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