Acute myocarditis following Comirnaty vaccination in a healthy man with previous SARS-CoV-2 infection.

Myopericarditis following mRNA Covid-19 vaccination has recently been reported to health authorities in a lot of countries. They can occur in very rare cases after either the Moderna (mRNA-1273 - Spikevax) or Pfizer-BioNTech (BNT162b2 - Comirnaty) vaccination. Cases predominately occur in younger adult men within 14 days following the second dose.

[Under-reporting of adverse drug reactions, a problem that also involves medicines subject to additional monitoring. Preliminary data from a single-center experience on novel oral anticoagulants].

Background: Spontaneous reporting system is the most widely used method by pharmacovigilance centers. Its "voluntary nature" represents the main cause of adverse drug reaction (ADR) under-reporting phenomena. The aim of this study was to point out the issue of ADR under-reporting from doctors, particularly serious ADRs and adverse reactions caused by medicinal products subject to additional monitoring, such as novel oral anticoagulants (NOACs).

Pulmonary tumor thrombotic microangiopathy: the challenge of the antemortem diagnosis.

Pulmonary tumor thrombotic microangiopathy (PTTM) is known as a rare and severe cancer-related pulmonary complication. Nowadays, fewer than 80 cases have been reported in the literature and very few cases have been diagnosed antemortem. We describe an autopsy case of PTTM associated with cancer of unknown origin.

[Dronedarone: a real innovation or a mere second-best choice? How to find the way among guidelines, regulatory agencies and daily clinical practice].

Dronedarone is the antiarrhythmic drug with the most complete and wide literature preceding its marketing. Most of these studies showed a good efficacy along with an excellent risk profile, especially in low- and medium-risk patients. Recently, updates of European, American and even Italian guidelines gave dronedarone its own spot into the antiarrhythmic armamentarium, recommending its use both for rhythm control and rate control in non-permanent atrial fibrillation.

The tensor apparatus in double-orifice mitral valve: interpretation of echocardiographic findings.

We describe a rare case of double-orifice mitral valve discovered with echocardiography. The tensor apparatus composed of four papillary muscles and anomalous attachment of chordae tendineae represents the main findings. Two supernumerary muscles in combination with the altered chordal insertion on the central portion of the anterior mitral leaflet are responsible for the V-shaped ("seagull wing") and spectacle-like features of the mitral valve in the short-axis view.

Diagnostic criteria and management of subacute ventricular free wall rupture complicating acute myocardial infarction.

In this prospective study we evaluated the value of the main diagnostic criteria for postinfarction subacute rupture of the ventricular free wall. Two-dimensional echocardiograms and recordings of right atrial pressure and waveform were immediately obtained in every patient exhibiting rapid clinical and/or hemodynamic compromise in the acute infarction setting. The same protocol was applied to patients referred from other hospitals for suspected myocardial rupture.

Comparison of impedance cardiography with thermodilution and direct Fick methods for noninvasive measurement of stroke volume and cardiac output during incremental exercise in patients with ischemic cardiomyopathy.

In the last decade, an inexpensive and simple noninvasive method (i.e., transthoracic electrical bioimpedance cardiography, has been tested in healthy subjects and patients with various heart disease for measuring stroke volume and cardiac output at rest and/or during exercise.

[Treatment of recurrent supraventricular tachyarrhythmias with flecainide or a flecainide and amiodarone combination].

The acute electrophysiologic effects and therapeutic efficacy of intravenous and oral flecainide were assessed in 18 patients with recurrent supraventricular tachyarrhythmias, resistant to conventional antiarrhythmic agents. They were 22 to 76 years old (mean 50). Twelve patients underwent electrophysiologic study for the investigation of tachyarrhythmias.

Monitored long-term treatment with ibopamine in patients suffering from severe congestive heart failure.

50 patients with congestive heart failure underwent monitored long-term treatment aimed at evaluating the effect of ibopamine (SB-7505), the 3,4-diisobutyryl ester of N-methyldopamine, on their condition. Ibopamine was administered alone or in combination with traditional therapy mainly at a dose of 100 mg t.i.

The diisobutyryl ester of N-methyldopamine, ibopamine: evaluation of electrophysiological properties and arrhythmogenicity studies.

The electrophysiological properties of ibopamine (SB-7505), the 3,4-diisobutyryl ester N-methyldopamine, was evaluated in 8 patients with syncopes of unknown etiology or with suspected disease of the sinus node or due to I-II degree AV block. A complete electrophysiological examination, including atrial and ventricular stimulation, was performed both in baseline conditions and within 1 h after oral administration of ibopamine 200 mg in a single dose. The study showed a slight reduction in effective refractory periods in the right atrium (-4.

[Echocardiographic and clinical correlations in infectious endocarditis of the left heart].

Unlabelled: The echocardiographic features were correlated with the clinical findings and outcome in 35 patients with aortic and/or mitral valve endocarditis. There were 26 males and 9 females with a mean age of 38 years. The infection involved native valves in 27 patients and prosthetic valves in 8 patients.

[Comparison of various indirect methods for evaluation of sinus function].

Sinus node function was evaluated by Mandel, Strauss and Narula's methods in 60 consecutive patients: 20 females, 40 males; average age 59 +/- 17 years. Three had second degree sinoatrial block, 2 had bradycardia-tachycardia syndromes and 10 had sinus bradycardia. The corrected sinus node recovery time was 414 +/- 417 ms.

[Comparison of the anti-arrhythmic effects of propafenone and aprindine in the treatment of refractory chronic ventricular arrhythmias. A randomized double-blind crossover study controlled with placebo].

A placebo-controlled, randomized, double-blind, crossover study was performed in 14 patients with chronic, resistant, ventricular arrhythmias in order to evaluate the efficacy and safety of two new antiarrhythmic agents, propafenone and aprindine. After an initial placebo phase, patients received orally either propafenone (600 mg daily) or aprindine (150 mg daily for the first two days and 50 mg every 12 hours successively) for five days. This treatment was followed by a drug-free period (placebo II); patients were then crossed over to the alternative drug.

[Echocardiographic diagnosis of aneurysm of Valsalva's sinus with fistulization into the right atrium].

The preoperative diagnosis of an aneurysm of the posterior sinus of Valsalva with rupture into the right atrium was made by echocardiography in a 21-year-old patient. The M-mode echocardiography revealed the following findings: 1) a vibrating anomalous structure, continuous with the aortic wall, was present in the right atrium. The echo-producing mass was the wall of the aneurysm, which adhered to the septal leaflet of the tricuspid valve during early-to-mid systole and had an abrupt posterior motion in late systole.

[Aneurysm of the membranous septum associated with interventricular patency. Echocardiographic study].

It has been documented by others that spontaneous closure or diminution in size of membranous ventricular septal defect is often associated with aneurysmal formation of the membranous septum. In a series of 51 patients, who underwent cardiac catheterization and cineangiocardiography for evaluation of the severity of a ventricular septal defect, 7 patients showed an aneurysm of the membranous interventricular septum (VSA) associated with a small ventricular septal defect (VSD). M-mode echocardiography was useful in the detection of VSA in 6 of them.

[Echocardiographic patterns of congenital aneurysm of the sinus of Valsalva. Review of literature and report of three cases (author's transl)].

The (M-mode) echocardiographic patterns of three patients with congenital aneurysm of the right sinus of Valsalva are reported. In two patients the aneurysm ruptured into the right ventricular cavity. In the third case, in which the lesion was associated with coarctation of the aorta, no communication was shown between the aorta and other cardiac chambers.

[The tricuspid valve prolapse. Clinical significance and diagnostic problems (author's transl)].

Systolic prolapse of the tricuspid valve is a relatively unknown anatomo-clinical entity. In this communication etiology, clinical significance and diagnostic problems of this condition are reported and discussed. The frequent association with mitral valve prolapse and the coexistence of skeletal and cardiac anomalies strongly suggest the role of congenital factors and the degenerative nature of this valvular abnormality.

[Congestive heart failure in genetic hypertrophic cardiomyopathies (ASH) (author's transl)].

Of a total sixtytwo patients covering all the spectrum of genetic ASH, who were studied by heart catheterization, M-mode echocardiography and phonomechano cardiography, five patients (four with the obstructive variety of the disease) showed clinical evidence of chronic congestive heart failure with ankle edema and hepatomegaly (group I). Their data were compared with those of fifteen "obstructed" patients who were not in heart decompensation (group II). No statistically significant differences were found between groups I and II in terms of L.